Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation

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Abstract

We improved the specific radioactivity of the apoptosis imaging isatin derivative 18F-ICMT11. We then evaluated 18F-ICMT11 in EL4 tumor-bearing mice 24 h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115 ± 0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083 ± 0.008 SUV). This effect correlated to the observed increases in apoptotic index.

References and notes (36)

  • S. Zijlstra et al.

    Appl. Radiat. Isot.

    (2003)
  • J. Toretsky et al.

    Nucl. Med. Biol.

    (2004)
  • H. Keen et al.

    Nucl. Med. Biol.

    (2005)
  • B. Dekker et al.

    Nucl. Med. Biol.

    (2005)
  • B. Dekker et al.

    Nucl. Med. Biol.

    (2005)
  • M. Glaser et al.

    Appl. Radiat. Isot.

    (2003)
  • C.A.C. Beekman et al.

    Appl. Radiat. Isot.

    (2011)
  • A.K. Hammill et al.

    Exp. Cell Res.

    (1999)
  • U. Haberkorn et al.

    Nucl. Med. Biol.

    (2001)
  • D. Zhou et al.

    Bioorg. Med. Chem. Lett.

    (2006)
  • D.L. Chen et al.

    Nucl. Med. Biol.

    (2009)
  • G. Niu et al.

    J. Nucl. Med.

    (2010)
  • F.G. Blankenberg

    J. Nucl. Med.

    (2008)
  • M. Zhao

    Anti-Cancer Agents Med. Chem.

    (2009)
  • C.M.M. Lahorte et al.

    Eur. J. Nucl. Med. Biol. Imaging

    (2004)
  • J.R. Grierson et al.

    Bioconjugate Chem.

    (2004)
  • Y. Murakami et al.

    Eur. J. Nucl. Med. Mol. Imaging

    (2004)
  • K.J. Yagle et al.

    J. Nucl. Med.

    (2005)

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    Present address: Singapore BioImaging Consortium, HELIOS, 11 Biopolis Way, Singapore 138667, Singapore.

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