Spacer length effects on in vitro imaging and surface accessibility of fluorescent inhibitors of prostate specific membrane antigen
Graphical abstract
A series of spacer-varied imaging probes were synthesized and evaluated, which exhibited spacer length-dependent effects on inhibitory potency, mode of inhibition, and fluorescence imaging of prostate cancer cells.
Section snippets
Acknowledgments
The authors extend their gratitude for technical assistance to G. Helms and W. Hiscox at the WSU Center for NMR Spectroscopy, as well as C. Davitt and V. Lynch-Holm at the WSU Franceschi Microscopy and Imaging Center. This work was supported in part by the Washington State Life Sciences Discovery Fund (LSDF 08-01 2374880) and the National Institutes of Health (5R01CA140617-02).
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