A targeted low molecular weight near-infrared fluorescent probe for prostate cancer
Graphical abstract
A novel near-infrared imaging probe was synthesized, which exhibited potent PSMA inhibitory activity (IC50 = 0.55 nM) and PSMA-targeted imaging of prostate cancer cells in vitro.
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Acknowledgments
The authors extend their gratitude for technical assistance to G. Helms and W. Hiscox at the WSU Center for NMR Spectroscopy, Dr. C. Zhu at the WSU Department of Chemistry for mass spectrometry, and to both C. Davitt and V. Lynch-Holm at the WSU Franceschi Microscopy and Imaging Center. This work was supported in part by the Washington State Life Sciences Discovery Fund (LSDF 08-01 2374880) and the National Institutes of Health (1R21CA135463-01).
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