Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging

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Abstract

A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4 K) and 2,2′,2″,2‴-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After 64Cu labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation.

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Acknowledgments

The research was supported by Commonwealth Foundation for Cancer Research (D.P.) NIH Grants HL-073361 (J.L.) and HD051609 (K.D.F.).

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