Archival ReportProgression of Cerebral Amyloid Load Is Associated with the Apolipoprotein E ε4 Genotype in Alzheimer's Disease
Section snippets
Patient Recruitment, Inclusion, and Exclusion Criteria
Patients were recruited from the research outpatient unit for cognitive disorders at the Department of Psychiatry, Klinikum rechts der Isar, Technische Universitaet, Muenchen, Munich, Germany. They had been referred for the diagnostic evaluation of cognitive impairment by general practitioners, neurologists, psychiatrists, or other institutions and had undergone a standardized diagnostic procedure.
The diagnostic work-up included an interview with the patient and an informant; medical,
Patients
Informed consent was obtained from 42 patients. Of these, 18 did not participate in the follow-up examination and were excluded from the analysis. Four patients had died, five patients had become too ill to undergo PET or MRI examinations, and nine patients or their caregivers had withdrawn consent. The remaining 24 patients were included in the present study. The demographic data of the sample are provided in Table 1. All patients fulfilled diagnostic criteria of probable AD. Three patients
Discussion
In the current study we analyzed the change of C/cv [11C] PiB uptake ratios during a mean interval of 26.6 months in a sample of 24 patients with AD who were diagnosed clinically and with [18F] FDG-PET. The [11C] PiB uptake, which is an in vivo marker of cerebral amyloid deposition, showed a statistically significant increase within this relatively short time interval.
Tracer uptake at baseline and increased uptake at follow-up was most prominent in the neocortex, whereas relatively low baseline
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