Original articleReduced Serotonin-1A Receptor Binding in Social Anxiety Disorder
Section snippets
Subjects
Fourteen medication-free male outpatients with social anxiety disorder and 18 healthy male control subjects were scanned with PET. Two patients were excluded from analysis: one because of drug consumption prior to the scan, discovered afterwards, and the second because of missing structural magnetic resonance imaging (MRI). Details of subject characteristics including psychometric assessment results are given in Table 1. All healthy subjects and most of the patients were recruited from the
Comparison Between SAD Patients and Healthy Control Subjects
The multivariate ANOVA revealed a significant reduction of 5-HT1A BP in SAD patients compared with healthy control subjects (p = .041; Pillai’s Trace). Including age and radiochemical variables as covariates in the multivariate ANOVA, we found a highly significant reduction in 5-HT1A binding in the amygdala (p = .003; −21.4%, uncorrected for multiple comparison, post hoc t test), in the anterior cingulate cortex (p = .004; −23.8%), and in the insula (p = .003; −28.0%), and a significant
Discussion
We have demonstrated a significantly lower 5-HT1A receptor binding potential in male patients suffering from SAD than in an age-matched healthy control group. Significant 5-HT1A BP reductions (corrected for multiple tests) were found in the amygdala (−21.4%), the anterior cingulate cortex (−23.8%), and insula (−28.0%), indicating alterations in limbic and paralimbic areas of SAD patients. The reduction was most prominent in the raphe nuclei (−36.4%) but did not survive correction for multiple
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