Original articleGeneral thoracicIntraoperative Near-Infrared Imaging Can Identify Pulmonary Nodules
Section snippets
Study Design
This study was approved by the University of Pennsylvania Institutional Review Board and all patients gave informed consent. Any patient with a solitary lung nodule and who was enrolled for surgery was eligible for this study. All patients underwent computed tomography (CT) scanning with at least 0.1 cm slice thickness. The CT scan was reviewed by a radiologist to confirm the presence of a solitary pulmonary nodule. The patients were specifically consented for the possibility that additional
Near-Infrared Imaging Can Identify Pulmonary Nodules Intraoperatively
Between January and July 2012, 18 patients between the ages of 29 and 78 (mean 60) with a diagnosis of a solitary pulmonary nodule were evaluated in a thoracic surgical clinic (Table 1). A 1-mm fine-cut CT scan demonstrated a single pulmonary nodule or mass (0.8 to 11 cm, mean 2.8 cm). Due to surgeon and patient preference, 8 out of 18 patients had a preoperative biopsy by transthoracic or transbronchial needle aspiration that confirmed a neoplasm. The remaining 10 patients did not have a
Comment
The goal of this study was to determine if NIR imaging could identify pulmonary nodules during a lung resection. In this pilot study, 18 patients with a solitary pulmonary nodule underwent a thoracotomy after systemic injection of 5 mg/kg ICG. The NIR signal detected 91% of these primary nodules suggesting colocalization of the ICG to the nodules, and fluorescent microscopy confirmed the ICG was in the tumors. The NIR imaging interestingly also detected 5 additional nodules. The sensitivity for
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