Coronary artery diseaseComparison of Multislice Computed Tomography to Gated Single-Photon Emission Computed Tomography for Imaging of Healed Myocardial Infarcts
Section snippets
Patients and study protocol
Sixty-nine patients with previous myocardial infarct (>3 months before the study) who underwent 64-slice MSCT and gated myocardial perfusion SPECT to assess coronary artery disease were included in the study protocol. Myocardial infarct was documented as typical chest pain lasting >30 minutes, increased creatine kinase-MB protein and/or troponin-T, and typical electrocardiographic changes. Contraindications to MSCT included (supra) ventricular arrhythmias, renal insufficiency (serum creatinine
Results
The 69 patients included in the study had a history of 74 healed myocardial infarcts, and 5 patients had 2 previous infarcts. Clinical characteristics of the study population are listed in Table 1.
Discussion
The purpose of the present study was to evaluate the performance of MSCT in the detection and semiquantitative analysis of healed myocardial infarct in comparison to gated SPECT. Furthermore, relations between infarct score using MSCT and other parameters derived from MSCT (EDWT, WMSI, and LVEF) that also (indirectly) reflected infarct expansion were evaluated. In 62 patients (90%), regions of infarct were detected using gated SPECT at rest. Using MSCT, hypoenhanced areas could be shown in all
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- 1
J.D. Schuijf was supported by Grant No. 2002B105 from The Netherlands Heart Foundation, The Hague, The Netherlands.
- 2
Dr. Bax was supported by research grants from GE Healthcare, Milwaukee, Wisconsin, and BMS Medical Imaging, London, United Kingdom.