Coronary artery diseaseRelation of Myocardial Perfusion Defects and Nonsignificant Coronary Lesions by Angiography With Insights from Intravascular Ultrasound and Coronary Pressure Measurements
Section snippets
Study population
The study population consisted of 48 patients who had mild coronary stenosis (<50% diameter stenosis) in the proximal/middle segment of ≥1 coronary artery and had been included in a study of coronary atherosclerosis progression and regression. Patients who had another lesion in the evaluated coronary artery and/or had lesions with >50% diameter stenosis were excluded. The decision about patients’ treatment was left to the discretion of the cardiologist who was responsible for the patient, and
Results
Clinical characteristics of the study population are presented in Table 1. All patients underwent myocardial perfusion single-photon emission computed tomography, coronary angiography, IVUS, and FFR measurements, and no complications were observed with any of these explorations.
Discussion
The results of this study showed that, in a population of patients who had stable coronary disease, up to 23% of angiographically mild coronary lesions were associated with myocardial perfusion defects as determined by single-photon emission computed tomography. Angiographic severity of these lesions was similar to that of lesions that were not associated with myocardial perfusion defects, but a greater lesion plaque burden as determined by IVUS was demonstrated in the presence of perfusion
References (30)
- et al.
Clinical validation of intravascular ultrasound imaging for assessment of coronary stenosis severitycomparison with stress myocardial perfusion imaging
J Am Coll Cardiol
(1999) - et al.
Value of exercise electrocardiography in the detection of restenosis after coronary angioplasty in patients with one-vessel disease
Am J Cardiol
(1999) - et al.
Use of fractional flow reserve to assess the functional significance of intermediate coronary stenoses
Am J Cardiol
(2000) - et al.
Simultaneous dipyridamole/maximal subjective exercise with 99mTc-MIBI SPECTimproved diagnostic yield in coronary artery disease
J Am Coll Cardiol
(1997) - et al.
Intravascular ultrasound study of angiographically mildly diseased coronary arteries
J Am Coll Cardiol
(1993) - et al.
Atherosclerosis in angiographically “normal” coronary artery referencean intravascular ultrasound study with clinical correlations
J Am Coll Cardiol
(1995) - et al.
Correlation of coronary arterial remodeling determined by intravascular ultrasound with angiographic diameter reduction of 20% to 60%
Am J Cardiol
(2003) - et al.
Impact of coronary artery remodeling on clinical presentation of coronary artery diseasean intravascular ultrasound study
J Am Coll Cardiol
(2001) - et al.
Effect of acute myocardial infarction on the utility of fractional flow reserve for the physiologic assessment of the severity of coronary artery narrowing
Am J Cardiol
(2004) - et al.
Adequacy of intracoronary versus intravenous adenosine-induced maximal coronary hyperemia for fractional flow reserve measurements
Am Heart J
(2000)
Role of incremental doses of intracoronary adenosine for fractional flow reserve assessment
Am Heart J
Are high doses of intracoronary adenosine an alternative to standard intravenous adenosine for the assessment of fractional flow reserve?
Am Heart J
Clinical potential of intravascular ultrasound for physiological assessment of coronary stenosisrelationship between quantitative ultrasound tomography and pressure-derived fractional flow reserve
Circulation
Measurement of fractional flow reserve to assess the functional severity of coronary artery stenoses
N Engl J Med
Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the American Heart Association
Circulation
Cited by (0)
This study was supported by grants from the Sociedad Española de Cardiologia and the Redes Temáticas de Investigación Cooperativa, Instituto Carlos III (Red C03/01, RECAVA), Madrid, Spain.