N-terminal B-type natriuretic peptide predicts extent of coronary artery disease and ischemia in patients with stable angina pectoris
Section snippets
Patients
In the present study, 94 patients with symptoms suggestive of coronary artery disease who were referred to our institution for further evaluation were prospectively included. Inclusion criteria were stable angina pectoris (Canadian Cardiovascular Society [CCS] classes I–III), preserved left ventricular function (ejection fraction [EF] >45%), and the ability to perform exercise testing. Patients with acute coronary syndromes or angina pectoris at rest (CCS class IV), patients not in sinus
Results
In this series 94 patients (76% male) were included. The detailed baseline characteristics of the patients are given in Table I.There was no difference between the different subgroups in regard to sex, age, BMI, renal function, LVMI, left ventricular EF, left ventricular end-diastolic pressure, prior history of myocardial infarction or coronary intervention, cardiovascular risk factors, and medical pretreatment with the exception of nitrates, which were more frequently given in patients with 3
Discussion
In several studies on patients with ST-elevation myocardial infarction, non-ST–elevation myocardial infarction, and unstable angina pectoris, an elevation of BNP and NT-proBNP has been observed.5, 6 These markers have proven to be of additional prognostic value. In the present study we demonstrated that NT-proBNP is also elevated in patients with chronic CAD and that it is of additional diagnostic value in these patients. This is, to our knowledge, the first study to evaluate the diagnostic
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