Original investigationUsefulness of 18F-FDG PET–Directed Skeletal Biopsy for Metastatic Neoplasm
Section snippets
Materials and methods
Human Subjects Committee Institution Review Board approval was obtained for this investigation. Between 2000 and 2004, we reviewed a series of patients with history of a primary malignancy that had undergone bone biopsy for suspected metastases. In one group of subjects, PET scan had been used to direct bone biopsy (PET-directed group), whereas in the other group bone scintigraphy was applied for that purpose (bone scintigraphy–directed group) as documented by the indication in the image-guided
Results
Of the population studied, 62 subjects were enrolled. The PET-directed group consisted of 34 subjects with a mean age of 60.5 ± 12.3 years including 53% (18/34) females. The bone scintigraphy directed–group consisted of 28 subjects with a mean age of 58 ± 14.7 years including 61% (17/28) females. Table 1 lists the prevalence of primary malignancy types in each group. There was no significant difference between the two groups with regard to the frequency of the primary malignancy. The frequency
Discussion
This retrospective investigation compared PET-directed with bone scintigraphy–directed skeletal biopsies for patients with a suspected bone metastases showed that both result in a high diagnostic yield with a nonsignificant trend for improved performance using PET as the directing modality.
PET imaging, which is based on the uptake of 18F-FDG in cells proportional to their glycolytic rate, is considered to be the “gold” standard in metabolic imaging. 18F-FDG also provides a quantitative means of
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