Elsevier

Oral Oncology

Volume 39, Issue 2, February 2003, Pages 130-137
Oral Oncology

Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread

https://doi.org/10.1016/S1368-8375(02)00030-1Get rights and content

Abstract

The prognostic significance of extracapsular spread of cervical metastases in oral cancer is still controversial. To investigate the importance of extent of extracapsular spread; the relationship between extracapsular spread and both traditional measures of metastatic disease and clinical/histological features of the primary tumour, and to determine their relative prognostic significance. The survival of 173 patients undergoing radical surgery and simultaneous neck dissection for oral/oropharyngeal squamous cell carcinoma with histologically confirmed nodal metastasis and followed for 2.2–12.3 years is reported and related to pathological features. The most predictive clinical/histopathological features were determined by Cox regression modelling. The 3-year survival probability was similar for patients with macroscopic and only microscopic extracapsular spread (33 and 36%, respectively, compared with 72% for patients with intranodal metastasis). The Cox model showed the most predictive factor was extracapsular spread followed by status of resection margins. Extracapsular spread should be incorporated into pathological staging systems. Even microscopic extracapsular spread is of critical importance and must be sought especially in small-volume metastatic disease.

Introduction

The presence of cervical lymph node metastasis is universally accepted as the main factor influencing survival in patients with squamous cell carcinoma of the oral and oropharyngeal mucosa (OSCC). In recent years, extranodal extension (extracapsular spread) of the metastatic tumour has been reported as a major prognostic factor by several independent workers [1], [2], [3], [4], [5], [6], [7]. In a previous study [8], we reported a 21% 5-year actuarial survival probability for patients with extracapsular spread (ECS) compared with a 64% survival probability for patients with intranodal metastases. Despite the strong, independent evidence, extranodal spread was only recorded as having controversial significance in a recent Medline review of the reliability and utility of prognostic factors in head and neck cancer [9]. In contrast, the pathological N stage [10], number and anatomical level of positive nodes were all recorded as having proven significance [9]. The significance of the extent of ECS is another contentious issue, particularly when patients receive post-operative radiotherapy [1], [4], [5], [11], [12], [13], [14], [15]. The controversy is compounded by inconsistencies in diagnosing the presence and extent of ECS and the lack of uniform terminology [1], [3], [11], [16]. Since October 1989, all neck dissections from patients treated at the Regional Centre for Maxillofacial Surgery at the University Hospital Aintree, Liverpool, UK, have been reported by a single pathologist (JAW) who follows the proposals of Carter et al. [16] and summarises the descriptive account of the extent of ECS as “macroscopic” or “microscopic”. Macroscopic ECS is evident to the naked eye during the laboratory dissection of the resection specimen and later confirmed by histological assessment. Its extent ranges from involvement of the perinodal fibro-adipose tissue to invasion of surrounding structures [16], [17]. Microscopic ECS is not suspected during the laboratory dissection and is only evident on histologic assessment [16]. It is almost always limited to the immediate perinodal fibro-adipose tissue [17]. The main purpose of the present study is to investigate the prognostic significance of only microscopic ECS. In addition, we will explore the relationship between ECS and the other more traditional histologic measures of the extent of nodal disease (number and size of metastatic nodes) that form the basis of the current UICC staging system [10] as well as clinical and histologic features of the primary tumour, and determine their relative prognostic significance.

Section snippets

Surgical cases

A series of 173 consecutive patients undergoing surgery as the primary treatment for OSCC at the Regional Centre for Maxillofacial Surgery, University Hospital Aintree, Liverpool, UK, between October 1989 and December 1999, and found on histological assessment of the resection specimen to have cervical lymph node metastasis, formed the material for the study. None of the patients had received pre-operative radiotherapy, chemotherapy or previous oro-maxillofacial surgery, other than routine

Histological findings

The pathological T stage [10] was pT1 in 20 cases (12%), pT2 in 50 (29%), pT3 in 17 (10%) and pT4 in the remaining 86 cases (50%). The resection margins were clear in 60 cases (35%), close in 87 (50%) and involved in the remaining 26 cases (15%).

An average of 48 lymph nodes was examined in the radical neck dissections, 40 nodes in the modified level I–V procedures and 25 nodes in selective level I–III/IV procedures. Twenty-eight of the 173 patients (16%) had bilateral positive nodes. Hence, 201

Discussion

The present study provides additional strong evidence of the prognostic significance of ECS in the survival of patients with cervical lymph node metastases from OSCC. Our results clearly show the importance of even microscopic ECS. Although patients with obvious macroscopic ECS die more quickly, the outcome by three years after surgery is exactly the same despite the use of post-operative radiotherapy. The Cox regression shows that ECS is a more important predictor than the nodal features of

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