Original articleDiagnostic accuracy of antimyosin scintigraphy in suspected myocarditis
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2013, European Journal of RadiologyCitation Excerpt :CCT also demonstrates characteristic findings such as cardiomegaly and LV dilation. Antimyosin scintigraphy is a modality that can identify myocardial inflammation with a high sensitivity (91–100%) and negative predictive value (93–100%) but low specificity (31–44%) and positive predictive value (28–33%) [19]. Antimyosin antibody (111In-Antimyosin) is administered intravenously and localizes in necrotic myocytes.
Molecular Imaging Approaches for Evaluation of Myocardial Pathophysiology: Angiogenesis, Ventricular Remodeling, Inflammation, and Cell Death. Angiogenesis, Ventricular Remodeling, Inflammation, and Cell Death.
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2009, Mayo Clinic ProceedingsCitation Excerpt :However, the utility of endomyocardial biopsy is limited because of sampling error from patchy inflammatory infiltrates and variability in observer interpretation.28 In a large case series, the sensitivity of endomyocardial biopsy was only 35% compared to a clinical criterion standard that included recovery of myocardial function.29 Immunostains for cell specific markers such as T lymphocytes (CD3) or macrophages (CD68) or human leukocyte antigens have a sensitivity of up to 50%, which is much better than routine histologic techniques.30,31