Original articleComparison between dipyridamole and adenosine as pharmacologic coronary vasodilators in detection of coronary artery disease with thallium 201 imaging
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Coronary Artery Disease Detection: Pharmacologic Stress SPECT. Pharmacologic Stress SPECT.
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2008, Revista Espanola de Cardiologia SuplementosDirect comparison of adenosine and adenosine 5′-triphosphate as pharmacologic stress agents in conjunction with Tl-201 SPECT: Hemodynamic response, myocardial tracer uptake, and size of perfusion defects in the same subjects
2006, Journal of Nuclear CardiologyCitation Excerpt :Although ATP has a greater initial action, adenosine as the metabolic product of ATP then plays a role in maintaining vasodilation.18 As such, when 2 pharmacologic stress agents with similar effects and indications, such as adenosine and ATP, are available for the diagnosis of coronary artery disease, a comparison of the diagnostic accuracy, technical feasibility, incidence of side effects, and cost is important for routine clinical application.4 The overall sensitivity and specificity of Tl-201 SPECT imaging with ATP for coronary artery disease detection are 84% to 92% and 87% to 89%, respectively, which are similar to those reported with adenosine or dipyridamole.19-21
Effect of Caffeine on Ischemia Detection by Adenosine Single-Photon Emission Computed Tomography Perfusion Imaging
2006, Journal of the American College of CardiologyCitation Excerpt :This is an important difference because caffeine is a competitive inhibitor, which means that the very high adenosine interstitial concentration may overwhelm the receptors and continue to produce coronary hyperemia. This difference between adenosine and dipyridamole is seen as a more robust blood pressure decrease and heart rate increase and more defect severity and extent with adenosine compared with dipyridamole (26–28). Further, even if the degree of hyperemia is slightly reduced, it may have no important impact on the results of perfusion imaging because the tracer extraction levels off at flow rates above 2.5-fold of the baseline flow.
Myocardial perfusion imaging with adenosine triphosphate predicts the rate of cardiovascular events
2006, Journal of Nuclear Cardiology