Regular ArticleEvaluation of the Reference Tissue Models for PET and SPECT Benzodiazepine Binding Parameters
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2017, Nuclear Medicine and BiologyCitation Excerpt :Therefore, an effect of isoflurane could be expected in GABAA receptors of all animals, which should not interfere in group comparisons. While the pons is a well-accepted reference tissue, it is not entirely devoid of GABAA receptors [44–46]. In fact, no brain regions can be considered completely GABAA receptor free [25,26].
A single-scan protocol for absolute D<inf>2/3</inf> receptor quantification with [<sup>123</sup>I]IBZM SPECT
2017, NeuroImageCitation Excerpt :The mutli-injection approach can be considered a “gold-standard” in modeling radiotracer kinetics in the brain, permitting an in-depth decomposition of the radioactive signal and full quantification of kinetic parameters, to our knowledge more than any other approach. Its use to validate simpler quantitative methods is invaluable (Dumas et al., 2015; Millet et al., 2002, 2000a, 2006, 2012). However, the estimation of a high number of parameters through a very complex protocol naturally comes at a cost.
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2014, Nuclear Medicine and BiologyCitation Excerpt :Obviously, performing scans of minimal duration, employing a model that requires no blood sampling and yet obtaining accurate parameters is a critical factor for the success of clinical and preclinical experiments. All these questions have been thoroughly assessed in human and other primate studies regarding kinetic, graphical and equilibrium analyses [7,20,22,23,33,40–42]. Nevertheless, no study on rodent GABAA quantification with SPECT exists.
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