Viruses in the treatment of brain tumors
Section snippets
Background
The original descriptions of viruses were as disease-causing agents with restrictions for intracellular multiplication, whose size allows them to pass through ultrafine filters that retain even the smallest of bacteria [6]. More recent observations have created the image of viruses as mobile genetic elements enclosed most often by a protein capsid (and at times further enclosed by a lipid bilayer envelope) that is permissive of their movement from one cell to another. The viral genome encodes
Clinical strategy and trials: attenuated herpes simplex virus for selective lysis of malignant glioma cells
Not all antineoplastic applications for viruses have entailed their use as gene delivery agents. For over 90 years, the ability of viruses to instigate lytic infections has prompted research into their potential for selective lysis of tumor cells. The first published report of viral oncolysis, albeit following nonintentional exposure, dates back to 1912, when De Pace, an Italian gynecologist, observed spontaneous remission of cervical cancer in women who were immunized with a live attenuated
Summary
The grave outlook for malignant glioma patients in spite of improvements to current modalities has ushered in new approaches to therapy. Viruses have emerged on the scene and gained attention for their ability to play essentially two roles: first, as vectors for therapeutic gene delivery and second, as engineered infectious agents capable of selectively lysing tumor cells. To date, clinical brain tumor trials using viruses for gene delivery have employed retroviral or adenoviral vectors to
Acknowledgements
The authors thank Rita Rollins for her invaluable assistance with research and the Duke University Division of Medical Photography for its help with figures.
References (128)
Gene therapy for brain tumors: the fundamentals
Surg Neurol
(2000)- et al.
Methods of gene delivery
Hematol Oncol Clin North Am
(1998) - et al.
Gene therapy for malignant gliomas
Hematol Oncol Clin North Am
(1998) - et al.
Inhibition of herpes simplex virus transformed and nontransformed cells by acycloguanosine: mechanisms of uptake and toxicity
Virology
(1981) - et al.
Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information
Virology
(1980) - et al.
Gene therapy using retroviral vectors
Curr Opin Biotechnol
(1994) - et al.
Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis
Cell
(1993) - et al.
Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis
Virology
(1996) Lentiviruses as gene transfer agents for delivery to non-dividing cells
Curr Opin Biotechnol
(1998)Removal of right cerebral hemisphere for certain tumors with hemiplegia
JAMA
(1928)
Treatment of malignant glioma: a problem beyond the margins of resection
J Cancer Res Clin Oncol
Chemotherapy and immunotherapy of malignant glioma: molecular mechanisms and clinical perspectives
Cell Mol Life Sci
Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials
J Natl Cancer Inst
Viruses as therapeutic agents against malignant disease of the central nervous system
J Natl Cancer Inst
Basic genetic mechanisms
Gene therapy and other molecular genetic-based therapeutic approaches
Gene therapy for brain tumors
Current Oncology Reports
A glial-specific, repressible, adenovirus vector for brain tumor gene therapy
Cancer Res
Gene transfer into humans–immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction
N Engl J Med
The ADA human gene therapy clinical protocol: points to consider response with clinical protocol, July 6, 1990
Hum Gene Ther
Lymphocyte gene therapy
Hum Gene Ther
Correction of ADA deficiency in human T lymphocytes using retroviral-mediated gene transfer
Transplant Proc
Death but one unintended consequence of gene-therapy trial
CMAJ
Clinical trials end at gene-therapy institute
Nature
Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas
J Neurosurg
Extraneural metastases of astrocytomas and glioblastomas: clinicopathological study of two cases and review of literature
Cancer
The biochemistry and mechanism of action of acyclovir
J Antimicrob Chemother
Anticellular effects of 9-(2-hydroxyethoxymethyl) guanine against herpes simplex virus-transformed cells
J Gen Virol
Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy
Cancer Res
Targeting of an inducible toxic phenotype in animal cells
Proc Natl Acad Sci USA
Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line
J Neurosci Res
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene
New Biologist
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
Science
Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors
Am J Respir Cell Mol Biol
Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system
Cancer Res
Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene
Ann Surg
Regression of established macroscopic liver metastases after in situ transduction of a suicide gene
Proc Natl Acad Sci USA
Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector
Proc Soc Exp Biol Med
Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines
J Immunother
Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection
Mol Cell Biol
Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
Hum Gene Ther
RNA-dependent DNA polymerase in virions of RNA tumour viruses
Nature
Targeting of retroviral vectors for gene therapy
Hum Gene Ther
Immunity to homologous grafted skin: III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye
British Journal of Experimental Pathology
Transfer of genes to humans: early lessons and obstacles to success
Science
The basic science of gene therapy
Science
High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range
Proc Natl Acad Sci U S A
Retrovirus packaging cells
Hum Gene Ther
The effects of human serum and cerebrospinal fluid on retroviral vectors and packaging cell lines
Hum Gene Ther
Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors
J Neurosurg
Cited by (10)
Molecular Imaging of Gene Therapy for Neurogenetic Diseases
2006, Gene Therapy of the Central Nervous System: From Bench to BedsidePoliovirus vaccine strains as mucosal vaccine vectors and their potential use to develop an AIDS vaccine
2004, Advanced Drug Delivery ReviewsPHOTODYNAMIC THERAPY IN NEUROONCOLOGY
2023, Biomedical PhotonicsMolecular imaging with reporter genes: Has its promise been delivered?
2019, Journal of Nuclear MedicineImmunotherapy for primary brain tumors: No longer a matter of privilege
2014, Clinical Cancer Research