Evaluation of carbon-11 labeled KF15372 and its ethyl and methyl derivatives as a potential CNS adenosine A1 receptor ligand☆
References (25)
- et al.
The effect of adenosine on the development of long-term potentiation
Neurosci. Lett.
(1990) - et al.
Selective alteration in glutamate receptor subtypes after unilateral orbital enucleation
Brain Res.
(1991) - et al.
Synthesis and preliminary evaluation of [11C]KF15372, a selective adenosine A1 antagonist
Appl. Radiat. Isot.
(1995) - et al.
The impact of postsynaptic calcium on synaptic transmission—its role in long-term potentiation
Trends Neurosci.
(1989) - et al.
KF17837 ((E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine), a potent and selective adenosine A2 receptor antagonist
Eur. J. Pharmacol.
(1994) - et al.
Differential localization of adenosine A1 receptors in the rat hippocampus: quantitative autoradiographic study
Brain Res.
(1988) - et al.
Effect of xanthine derivatives on hippocampal long-term potentiation
Brain Res.
(1990) - et al.
Purinoceptor nomenclature: A status report
Drug Dev. Res.
(1993) - Barthrup J. T. and Stone T. W. Activation of NMDA a receptorcoupled channels suppresses the inhibitory action of...
- et al.
Adenosine receptors in brain membranes: Binding of 6N-cyclohexyl [3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine
Adenosine receptors in brain: neuromodulation and role in epilepsy
Ann. Neurol.
Adenosine receptors: targets for future drugs
J. Med. Chem.
Cited by (54)
The chemistry of labeling heterocycles with carbon-11 or fluorine-18 for biomedical imaging
2020, Advances in Heterocyclic ChemistryCitation Excerpt :The amide nitrogen, C-5 carbon and 2-carbonyl group are potential sites for labeling uracils with carbon-11. 11C-N-Methylation was efficient for the synthesis of [11C]365 from 364 (Scheme 114A) (2001NMB281) and [11C]367 from 366 (Scheme 114B) (1997NMB53). Bases and conditions need to be carefully selected to avoid labeling at the 7-position in [11C]367.
Human Brain Imaging of Adenosine Receptors
2014, Imaging of the Human Brain in Health and DiseaseAdenosine receptor PET imaging in human brain
2014, International Review of NeurobiologySynthesis and evaluation of [<sup>11</sup>C]FR194921 as a nonxanthine-type PET tracer for adenosine A<inf>1</inf> receptors in the brain
2005, Nuclear Medicine and BiologyAdenosine and Brain Function
2005, International Review of NeurobiologyCitation Excerpt :The general distribution of A1Rs is similar between rodents and humans (Fastbom et al., 1987; Schindler et al., 2001; Svenningsson et al., 1997). Initial attempts to localize A1Rs in the living brain using [11C]KF 15372 and [11C]MPDX and positron emission tomography (PET) have been made (Noguchi et al., 1997; Shimada et al., 2002). A2AR mRNA is highly enriched in the striatum (Fink et al., 1992; Schiffmann et al., 1991b; Svenningsson et al., 1997).
- ☆
This work was supported by Grants-in-Aid for Scientific Research (C) No 07807068 and (A) No 08557045 from the Ministry of Education, Science and Culture, Japan.