2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors
A series of novel 2-heterosubstituted pyridine is described as selective COX-2 inhibitors from which several potent and orally bioavailable analogs were found to be very active in rat models of inflammation, pyrexia, and pain.
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