Advances in the early detection, diagnosis, and staging of pancreatic cancer

doi:10.1016/S0960-7404(97)00025-X

Surgical Oncology

Volume 6, Issue 3, November 1997, Pages 157-169

https://doi.org/10.1016/S0960-7404(97)00025-X Get rights and content

Abstract

Pancreatic cancer is an aggressive disease with a dismal prognosis. It has long been regarded as one of the most difficult cancers to accurately diagnose and stage preoperatively. The purpose of this review is to provide an update of the state-of-the-art for early detection, diagnosis, and staging of pancreatic cancer. These methods include spiral CT scans, magnetic resonance imaging, positron emission tomography (PET) imaging, laparoscopy, endoscopic ultrasound, CA 19-9 serology, fine needle aspiration cytology, ERCP brush cytology, and screening for p53 and ras oncogenes. These advanced techniques should help us to detect pancreatic cancers in high-risk populations at a curative stage and to decrease pancreatico-duodenectomies for benign disease which could otherwise be treated with less morbid procedures. In addition, these tests will help reliably diagnose pancreatic cancer preoperatively.

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Pancreatic adenocarcinoma is one of the most aggressive cancers and has a rising incidence and high mortality. The high mortality rate is attributed to a lack of adequate diagnostics, which limits the efficacy of the few currently available treatment options. The poor prognosis of pancreatic cancer emphasizes an increasing demand to develop efficient diagnostic markers and therapeutic approaches. The current review focuses on advances made in the development of robust molecular biomarkers that can be used for diagnosis and targeted therapies. Here, we discuss three major types of molecular markers for the detection of pancreatic adenocarcinoma: serum, tumor tissue, and cancer stem cell markers. Substantial advances have been made to improve our understanding of pancreatic adenocarcinoma at both the cellular and molecular levels, strengthening the possibilities of early detection and targeted therapies; they are discussed in this chapter.
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ReviewAdvances in the early detection, diagnosis, and staging of pancreatic cancer

Abstract

Revue Medecine Interne

Clinical Radiology

Nuclear Medicine and Biology

Gastrointestinal Endoscopy

American Journal of Surgery

European Journal of Cancer and Clinical Oncology

Gastroenterology

Gastroenterology

Cancer of the pancreas

Familial pancreatic cancer: a review

Pancreatic ductal adenocarcinoma: diagnosis and staging with dynamic CT

Radiology

A comparison of conventional and spiral CT: an experimental study on the detection of spherical lesions

Journal of Computer Assisted Tomography

Spiral CT of the pancreas

Radiology

Spiral CT of the pancreas with multiplanar display

American Journal of Radiology

Potentially resectable pancreatic adenocarcinomas

Radiology

Helical CT evaluation of arterial invasion in pancreatic tumors: comparison with angiography

Abdominal Imagery

MR imaging of pancreatic disorders

Topics in Magnetic Resonance Imaging

Adenocarcinoma of the pancreatic ducts: comparative evaluation with CT and MR imaging at 1.5T

Radiology

Small pancreatic adenocarcinoma: efficacy of MR imaging with fat suppression and gadolinium enhancement

Radiology

Pancreatic disease: prospective comparison of CT, ERCP, and 1.5T MR imaging with dynamic gadolinium enhancement and fat suppression

Radiology

Pancreatic tumors; evaluation with endoscopic US. CT, and MR imaging

Radiology

Static and dynamic MR tomography of the pancreas: contrast media kinetics of the normal pancreatic parenchyma in pancreatic carcinoma and chronic pancreatitis

Rofo Fortschrift Geb Rontgenstr Neuen Verf

Normal abdominal enhancement patterns with dynamic gadolinium-enhanced MR imaging

Radiology

Pancreatic adenocarcinoma: CT versus MR imaging in the evaluation of resectability—report of the Radiology Diagnostic Oncology Group

Radiology

Positron emission tomography (PET) with fluorine-18-labeled deoxyglucose (FDG) for the detection of pancreatic cancer: comparison with CT, ultrasonography (US), and ERCP

Journal of Nuclear Medicine

Differentiation of malignant from benign pancreatic tumors by FDG-PET: comparison with CT, US, and endoscopic ultrasonography

Journal of Nuclear Medicine

FDG-PET evaluation of indeterminate pancreatic masses

Journal of Computer Assisted Tomography

F-18 fluorodeoxyglucose PET in vivo evaluation of pancreatic glucose metabolism for detection of pancreatic cancer

Radiology

Pancreatic neoplasms: how useful is evaluation with US?

Radiology

Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients

European Journal of Nuclear Medicine

Identification and characterization of muscarinic receptors in cultured human pancreatic carcinoma cells

Pancreas

Endoscopic ultrasonography in the diagnosis and staging of pancreatic adenocarcinoma: results of a prospective study with comparison to ultrasonography and CT scan

Endoscopy

Staging of pancreatic carcinoma by endoscopic ultrasonography

Endoscopy

Pancreatic tumors: evaluation with endoscopic US. CT, and MR imaging

Radiology

The value of minimal access surgery in the staging of patients with potentially resectable peripancreatic malignancy

Annals of Surgery

Laparoscopic ultrasonography for hepatobiliary and pancreatic malignancy

British Journal of Surgery

Early experience of laparoscopic ultrasonography in the management of pancreatic carcinoma

Surgical Endoscopy

Impact of fine-needle biopsy on management of patients with carcinoma of the pancreas

American Journal of Radiology

Percutaneous fine-needle aspiration biopsy of the pancreas

Diagnostic Cytopathology

Review
Advances in the early detection, diagnosis, and staging of pancreatic cancer