Influence of heart rate on vessel visibility in noninvasive coronary angiography using new multislice computed tomography: Experience in 94 patients
Section snippets
Background
The reliable noninvasive assessment of coronary artery disease would constitute an important step forward in clinical cardiology. Promising results have been reported for electron beam computed tomography (EBCT) with high sensitivity and specificity in the detection of coronary artery stenoses. A limitation of this method was found to be the high incidence of motion artifacts, leading to 25% of unanalyzable vessel segments [1], [2]. The second noninvasive technology for noninvasive coronary
Patients' characteristics and study protocol
Between October 1999 and October 2000, 94 patients who were assigned for conventional selective coronary angiography were included in the present study. The study protocol had been approved by the local ethical committee and all patients gave informed consent. Major inclusion criteria was the indication to undergo invasive cardiologic diagnostics. Clinical exclusion criteria were: age <37 years, renal insufficiency (creatinine >1.5 mg/dl), unstable angina pectoris, acute myocardial infarction,
Results
The clinical characteristics of the study group are summarized in Table 1, and the concurrent medication in Table 2. All patients had a sinus rhythm; mean heart rate of the whole study group was 67.1±11.5 bpm.
Sixty-five of ninety-four (69%) patients (pts) were on β-blocker therapy. These patients had a significantly lower heart rate (HR) than patients without β-blockers (65.1±10.7 bpm vs. 71.6±12.2 bpm, P=.01, see Fig. 4).
Discussion
The most important finding of the present study is that vessel visibility in noninvasive coronary angiography using MSCT is highly dependent on the patient's heart rate.
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Both authors contributed equally in performing the study, analyzing the data and preparing the manuscript.