Biology contribution
Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays

https://doi.org/10.1016/S0360-3016(96)00539-1Get rights and content

Abstract

Preliminary data establishes pimonidazole as a useful probe for human tumor hypoxia. Although different in chemical structure and properties, pimonidazole is indistinguishable from other markers in its binding to hypoxic cells in human tumors. Pimonidazole hydrochloride is convenient to administer and is well tolerated when given as single intravenous infusion of 0.5 g/m2. Comparison of immunostaining for pimonidazole binding and for PCNA or MIB-1 shows an inverse relationship between proliferation and hypoxia.

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