Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism?
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2022, Metabolic EngineeringCitation Excerpt :The purpose of CAF-induced upregulation of oxidative PPP is perhaps to maintain the redox balance and support the increased demand for nucleotide synthesis in tumor proliferation. Like previous studies, our analysis demonstrates that cells can decouple oxidative and non-oxidative PPP (Ying et al., 2012; Boros et al., 1998). Third, CAFs inhibit the TCA cycle, increase glutamine uptake, and stimulate glutaminolysis in CRC cells.
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2021, International Journal of Biological MacromoleculesThe redox requirements of proliferating mammalian cells
2018, Journal of Biological ChemistryCitation Excerpt :The oxidative pathway, which generates two molecules of NADPH per molecule of Rib-5-P produced, is proposed to be the primary source of Rib-5-P for biosynthesis in many proliferating cells (80, 81); however, the nonoxidative pathway may play a greater role in contexts where NADPH is abundant, as it is a potent inhibitor of the oxidative branch. Indeed, some cancers have been reported to preferentially obtain ribose from the nonoxidative pentose phosphate pathway (81–83), arguing the NADPH may not be limiting in those cells. Nucleotide base biosynthesis is closely linked to amino acid metabolism, requiring both amino acids and one-carbon units generated from amino acid catabolism (Fig. 4).
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