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2008, Bioscience HypothesesCitation Excerpt :Supporting evidence for a primary role of CBF in mental health is suggested by the pathophysiology of neurological disorders. Impaired cerebral blood flow has been implicated in mild cognitive impairment [26], dementias including AD [27–29], ADHD [30], depression [31], and schizophrenia [32,33]. BBB dysfunction has also been associated with several central nervous system (CNS) pathologies and in many of these cases cooperation between astrocytes and endothelium is implicated.
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