ArticlesNeuropathological Diagnosis of Alzheimer’s Disease: A Perspective from Longitudinal Clinicopathological Studies
Section snippets
Neurofibrillary Tangles and Other Cytoskeletal Pathology
The cardinal pathological feature of AD, which has been known since Alzheimer’s original descriptions, is neurofibrillary degeneration, and more specifically neurofibrillary tangles (NFTs). Biochemical, molecular biological, and modern neuropathological methods have increased our understanding of the nature of the paired helical filaments (PHFs) that are the major ultrastructural component of NFTs. Biochemical analyses of brains with many NFTs have demonstrated that the major protein component
Clinicopathological Studies of Aging and Dementia
Few postmortem analyses of prospective, longitudinal clinical studies of elderly people have been reported; however, the number of studies dealing with differences between aging and AD are now considerable. Certain consistencies that emerge from these data will be discussed with reference to our own clinicopathological studies.
Histopathological Diagnosis of AD
With these historical perspectives and general comments as a preface, the following is a brief consideration of how we approach a histopathological diagnosis of AD.
Acknowledgements
This study was supported by National Institute on Aging Grants AG06803 and NIA03949.
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