Original paperOxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia
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Cited by (71)
Imaging of Tumor Hypoxia for Radiotherapy: Current Status and Future Directions
2020, Seminars in Nuclear MedicineCitation Excerpt :These studies spurred the development of the clinically applicable pO2 histograph by Eppendorf in Germany (also known as the Eppendorf electrode). This methodology is often referred to as a gold standard, due to its direct measuring principle, and the fact that electrode measurements are strongly linked to poor prognosis in several cancers including head and neck and cervix squamous cell carcinomas, sarcomas, and prostate adenocarcinomas.54–62 Although biological differences affect inherent radiosensitivity (as discussed above), a key advantage of the electrode is that it actually measures pO2 directly, putatively providing an opportunity to estimate the relative influence of hypoxia on radiosensitivity (compared to full sensitization).
Imaging of hypoxia, oxygen consumption and recovery in vivo during ALA-photodynamic therapy using delayed fluorescence of Protoporphyrin IX
2020, Photodiagnosis and Photodynamic TherapyCitation Excerpt :A large number of different tools and methods have been developed for measurement of partial oxygen pressure (pO2) and oxygen saturation (StO2) in vivo in tissues [18,19]. The golden standard for absolute pO2 measurement has been a needle electrode, but this is invasive, consumes oxygen, and multiple punctures must be made to spatially map pO2 across the tumor [20]. Probes based on quenching of triplet states by oxygen provide a tool for accurate quantification of pO2.
A dual-functional luminescent probe for imaging H<inf>2</inf>S in living zebrafish and discrimination hypoxic cells from normoxic cells
2018, Sensors and Actuators, B: ChemicalOxygen imaging of living cells and tissues using luminescent molecular probes
2017, Journal of Photochemistry and Photobiology C: Photochemistry ReviewsCitation Excerpt :The oxygen needle electrode is the only technique that directly measures the oxygen concentration of tissues and has thus long been considered the gold standard [253–256] for such measurements. However, there are several disadvantages to using oxygen needle electrodes for measuring pO2 in tumors: (1) the needle itself is slightly invasive and potentially damages the tissue [257], (2) movement of the electrode through tissues of different densities (e.g., between tumors and normal/healthy tissues) can induce high pressure at the tip of the needle, resulting in inaccurate pO2 values [256], (3) a single point measurement by an oxygen needle electrode cannot adequately describe intra-tumoral heterogeneity in pO2 values [257,258], and (4) the signal-to-noise ratio (a measure of signal strength relative to background noise) is relatively low and can result in unreliable pO2 values [256]. Thus, the oxygen needle electrode is increasingly being used to complement recently developed noninvasive methods.
Molecular targeting of hypoxia in radiotherapy
2017, Advanced Drug Delivery Reviews