Special reports and reviews18-fluorodeoxyglucose positron emission tomography in nonendocrine neoplastic disorders of the gastrointestinal tract
Section snippets
Esophageal cancer
The incidence of esophageal cancer continues to increase rapidly and its epidemiology is changing; the percentage of cancers of the esophagus, which histologically are adenocarcinomas and therefore located at or near the esophageal-cardial junction, has been increasing substantially compared with squamous cell carcinoma.8
Diagnosis is established routinely through endoscopy and biopsy examination. After diagnosis, optimal patient management depends on accurate staging with curative esophagectomy
Gastric cancer
Cancer of the stomach bears an extremely poor prognosis. Its incidence in the Western World is increasing rapidly. Risk factors in the development of gastric cancer are diets rich in salted, smoked, or poorly preserved foods and Helicobacter pylori infection. Atrophic gastritis, pernicious anemia, gastric polyps, partial gastrectomy, Menetrier’s disease, and hereditary factors are other predisposing factors.30, 31 Conventional diagnostic imaging of primary gastric carcinoma is based
Liver tumors
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, with an annual incidence ranging from 30 in 100,000 people in Southeast Asia to 2 in 100,000 people in Northern Europe and the United States. Important risk factors for the development of HCC are alcohol abuse and chronic infection with hepatitis B or C virus.40, 41
Because only patients with small tumors (<5 cm) without extrahepatic metastases benefit from partial liver resection or transplantation as potentially
Biliary tract tumors
Cholangiocarcinomas, rare tumors of the gastrointestinal tract with an incidence of 2–4/100,000 per year, have a poor clinical course.54 They are a heterogeneous group of neoplasias that include the most common perihilar or Klatskin tumor (60%), the intrahepatic cholangiocarcinoma, the extrahepatic bile duct cancer, the gallbladder cancer, and the cancer of the ampulla of Vater.
The only potentially curative treatment approach currently available is surgery.55, 56 Because less than 20% of
Pancreatic cancer
Approximately 24,000 new cases of pancreatic cancer are diagnosed annually in the United States.64 The only curative treatment of pancreatic cancer is surgery, which is only performed on patients with limited tumor stages.65, 66 Thus, early diagnosis and accurate staging is necessary because the disease becomes incurable if the tissue surrounding the pancreas is invaded or distant metastases are found.
The crucial diagnostic problem is identifying pancreatic cancer in patients presenting with
Colorectal cancer
Colorectal cancer, the third most frequent cancer after prostate and lung cancer for men and after breast and lung carcinoma for women, kills 1 in every 2 people affected.86 Although colorectal cancer can be cured by standard or multivisceral resection including lymph node dissection, approximately 30% to 40% of patients will develop recurrent disease after initial treatment and this usually occurs within the first 2 years of treatment.87, 88 In recurrent colorectal cancer, a broad variety of
Esophageal cancer
For the purpose of preoperative staging, FDG PET can be advocated for M staging in patients suffering from esophageal carcinoma in whom conventional staging results are indeterminate or contradictory. T staging in these patients belongs to the morphologic imaging domain whereas N staging by FDG PET proved equally as disappointing as with EUS or CT. Available data on FDG-PET imaging for treatment monitoring in esophageal tumors are preliminary and additional studies are mandatory.
Gastric cancer
Available data
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