Can MRI predict the histopathological response in patients with osteosarcoma after the first cycle of chemotherapy?
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Inter-rater Variability in the Interpretation of Pre and Post Contrast MRI for Pre-Surgical Evaluation of Osteosarcoma in Long Bones in Pediatric Patients and Young Adults
2019, Surgical OncologyCitation Excerpt :Furthermore, for our purposes we believe that the pathology results are only truly of interest in the cases in which pre contrast only and pre and post contrast image interpretations were found to be discordant. The assessment of pathology results for other cases would address overall MRI performance, however this has been well assessed in the literature by multiple previous authors [9, 16, 17, 19, 22, 28]. We acknowledge that many surgeons and radiologists may prefer utilizing gadolinium, particularly for oncologic purposes, since this has been common practice for decades.
The significance of size change of soft tissue sarcoma during preoperative radiotherapy
2010, European Journal of Surgical OncologyCitation Excerpt :Tumour shrinkage and decreasing signal intensity on MRI in cervical carcinoma indicates a good response.13–15 In osteosarcoma, several studies have demonstrated the correlation between decrease in tumour size on MRI and pathologic response in patients treated with neoadjuvant chemotherapy.16–18 These studies report that increasing in tumour size correlates with a poor histological response, and conclude that change in tumour volume is an independent prognostic factor.
Diffusion-Weighted MR Imaging in Musculoskeletal Radiology: Applications in Trauma, Tumors, and Inflammation
2009, Magnetic Resonance Imaging Clinics of North AmericaCitation Excerpt :Furthermore, this method is invasive and unfavorable as a means of routine follow-up examinations. Conventional MR criteria may not be helpful in the early identification of good responders, and nested foci of residual viable tumor may be overseen.38,39 Instead, detection of necrosis has been recognized as a prognostic factor of tumor response to chemotherapy in Ewing sarcoma and osteogenic sarcoma.40
Effect of increases in tumor volume after neoadjuvant chemotherapy on the outcome of stage II osteosarcoma regardless of histological response
2009, Journal of Orthopaedic Science