Elsevier

Brain Research

Volume 852, Issue 1, 3 January 2000, Pages 228-232
Brain Research

Short communication
Loss of dopamine uptake sites and dopamine D2 receptors in striatonigral degeneration

https://doi.org/10.1016/S0006-8993(99)02205-2Get rights and content

Abstract

To explore the mechanisms underlying l-dopa response, we studied, by postmortem autoradiography, selective makers of dopamine presynaptic terminals, [3H]WIN 35428, and dopamine D2 receptors, [3H]nemonapride, in the putamen of four Parkinson's disease (PD) and one striatonigral degeneration (SND) neuropathologically confirmed brains as compared with six matched control brains. Dopamine uptake transporter was dramatically decreased (>90%) both in PD and SND striatum. Dopamine D2 receptors were preserved in PD, but clearly reduced (>76%) in the SND putamen. These data confirm that l-dopa response is closely associated with the preservation of striatal dopamine D2 receptors.

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