Original article: general thoracicNonanatomic prognostic factors in resected nonsmall cell lung carcinoma: the importance of perineural invasion as a new prognostic marker
Section snippets
Patients and methods
Between January 1998 and November 2002, 82 consecutive patients with histologic evidence of NSCLC were enrolled in the study after complete pulmonary resection and lymph node dissection. Routine blood tests included hemoglobin, alkaline phosphatase, and serum calcium estimations. All patients underwent postero-anterior and lateral chest radiographs and bronchoscopy. Computed tomographic scans of the thorax, abdomen (or abdominal ultrasonography), cranium, and all body bone scintigraphies were
Results
The main clinical and pathologic characteristics of the enrolled 82 patients are summarized in Table 1.
For the entire group, the mean follow-up period was 15.9 months (range, 1 to 43 months), and the median survival time was 45 months. The 1- and 3-year actuarial survival rates were 84.7% and 50.9%, respectively (Fig 2).
Univariable analyses revealed the following conventional prognostic factors as significant: surgical and pathologic N status (p = 0.027) and surgical and pathologic stage (p =
Comment
The staging system for NSCLC provides a framework for the assessment of prognosis and the assignment of therapy for all the patients. Similar to previous staging systems, the recent system has been established on a large database [2]. The power of this large database in prognosis is self-evident. Nevertheless, the inherent inaccuracy of the staging process should be brought to attention. According to the recent TNM system, the predicted 5-year survival after complete resection for T1N0 MO NSCLC
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