Experimental StudyRegional myocardial perfusion assessed with N-13 labeled ammonia and positron emission computerized axial tomography*
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Preclinical Imaging of Cardiovascular Disesase
2023, Seminars in Nuclear MedicineAnalysis of [<sup>11</sup>C]Choline and [<sup>13</sup>N]Ammonia using a single HPIC method
2021, Applied Radiation and IsotopesCitation Excerpt :[11C]Choline is a Food and Drug Administration (FDA) approved diagnostic agent for positron emission tomography (PET) imaging of biochemically recurrent prostate cancer (Grkovski et al., 2018; Hara et al., 1998). [ 13N]Ammonia is widely used as a drug for PET imaging of cardiac sarcoid (Dilsizian et al., 2016) or myocardial perfusion (Schelbert et al., 1979; Tio et al., 2009) in patients with suspected or existing coronary artery disease. As FDA approved PET drugs, quality control (QC) tests of both [11C]Choline and [13N]Ammonia include analyses of radiochemical purity, identity, chemical impurities, pH, osmolality, sterility, endotoxin, etc.
Simplified quantification of PET myocardial blood flow: The need for technical standardization
2020, Journal of Nuclear CardiologyClinical PET Myocardial Perfusion Imaging and Flow Quantification
2016, Cardiology ClinicsCitation Excerpt :PET has evolved tremendously over the last 40 years. From humble beginnings in brain imaging, limited at first to a few research centers in the 1960s and 1970s,1,2 PET has now grown to be a widely used modality in many disease areas. The development of numerous tracers imaging a wide range of biological pathways has lead to an ever-increasing reliance on PET in multiple clinical and research fields.
The coronary circulation and blood flow in left ventricular hypertrophy
2012, Journal of Molecular and Cellular CardiologyCitation Excerpt :These PET measurements of MBF, for which the symbol F/W is also used, have units of volume per time per unit weight of myocardium (i.e. ml/min/g) [11,16]. Different tracers can be used for measuring MBF using PET, including oxygen-15 labeled water (H215O) [17–21], 13NH3 [22–25] and the cationic potassium analog rubidium-82 (82Rb) [26,27]. 13NH3 and 82Rb are given intravenously as boluses.
Myocardial perfusion imaging using PET/CT
2011, Medecine Nucleaire
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This work was supported by Contract EY-76-C-03-0012 between the U. S. Department of Energy, Washington, D. C. and the University of California at Los Angeles.