Brief reportsEffect of metoprolol on absolute myocardial blood flow in patients with heart failure secondary to ischemic or nonischemic cardiomyopathy
References (13)
- et al.
13N-ammonia myocardial blood flow and uptakerelation to functional outcome of asynergic regions after revascularization
J Am Coll Cardiol
(1999) - et al.
Assessment of regional left ventricular function by sector analysisa method for objective evaluation of radionuclide blood pool studies
Am J Cardiol
(1983) - et al.
Enhanced regional left ventricular function after distant coronary bypass via improved collateral blood flow
J Am Coll Cardiol
(1989) - et al.
Improvement by propranolol of regional myocardial dysfunction and abnormal coronary flow pattern in conscious dogs with coronary narrowing
Am J Cardiol
(1978) - et al.
Comparative effects of cardioselective versus noncardioselective beta blockade on subendocardial blood flow and contractile function in ischemic myocardium
Am J Cardiol
(1979) - et al.
Regulation of coronary blood flow
Prog Cardiovasc Dis
(1975)
Cited by (26)
The Potential of Clinical Phenotyping of Heart Failure With Imaging Biomarkers for Guiding Therapies: A Focused Update
2017, JACC: Cardiovascular ImagingCitation Excerpt :Several positron emission tomography (PET) studies have demonstrated abnormal coronary flow reserve in dilated and hypertrophic cardiomyopathy patients, with the subset of patients exhibiting blunted flow reserve having a more unfavorable natural history (24,25). Such data support the relevance of the perfusion abnormalities rather than simply classifying them as false-positive if epicardial CAD is not present (26). On the other hand, extensive perfusion abnormalities in the setting of LV dysfunction are essentially always associated with CAD rather than with dilated cardiomyopathy, especially when the perfusion defects are segmental.
Cardiac PET/computed tomography applications and cardiovascular outcome
2015, PET ClinicsCitation Excerpt :PET assessment of MBF at rest and during different forms of vasomotor stress have been used to verify and follow up the effects of alterations in lifestyle, loss of body weight, and/or preventive medical care on coronary circulatory function in individuals with subclinical or with clinically manifest CAD.3,14,64 Flow responses to vasomotor stress or the coronary vasodilator capacity could be improved with antioxidant challenges, regular exercise, preventive medical care, and euglycemic control with antidiabetic medication in individuals with cardiovascular risk.65–69 More specifically, angiotensin II receptor blocker (ARB) with olmesartan was shown to restore endothelium-related MBF responses to CPT stimulation in patients with essential hypertension.70
Quantitative assessment of myocardial blood flow - Clinical and research applications
2014, Seminars in Nuclear MedicineCitation Excerpt :PET measurements of MBF may be used to monitor the effects of pharmacologic interventions or lifestyle modification on coronary circulatory function in patients with and without manifest CAD.10,81 For example, PET flow studies have been used to denote an improvement in endothelial dysfunction in patients with cardiovascular risk with a regular exercise program, preventive medical care, antioxidant supplementation with vitamin C, and euglycemic control with antidiabetic medication.140-144 In patients with untreated essential hypertension, angiotensin II receptor blocker (ARB) improved endothelium-related MBF increases to sympathetic stimulation with CPT.145
Journey in evolution of nuclear cardiology: Will there be another quantum leap with the f-18-labeled myocardial perfusion tracers?
2012, JACC: Cardiovascular ImagingCitation Excerpt :The clinical integration of quantitative rest and maximum MBF and absolute and relative MFR, assessed by PET, can now be used to guide invasive procedures and medical lifestyle treatment and their outcomes (25–29). Such quantitative PET flow measurements have been used to demonstrate improvement in endothelial dysfunction and myocardial ischemia in patients with advanced CAD after medical treatment, vitamin C, and a regular exercise program (26–32). Beyond the well-established diagnostic value of myocardial perfusion with PET, emerging data suggest the incremental prognostic value of absolute MBF and MFR in patients with suspected CAD.
Will 3-dimensional PET-CT enable the routine quantification of myocardial blood flow?
2007, Journal of Nuclear CardiologyMolecular imaging in heart failure
2007, Current Opinion in BiotechnologyCitation Excerpt :It is also likely that the beneficial effects of long-term β-adrenergic receptor and RAS antagonists in HF are, at least in part, due to a switch in cardiomyocyte metabolism from fatty acid to glucose uptake and oxidation [5••]. Favorable redistribution in absolute blood flow and associated increases in regional and global LV function have also been shown with β-adrenergic receptor blockers (Figure 1) [6]. Several nuclear molecular probes have been used to determine myocardial substrate utilization in HF.