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Effect of metoprolol on absolute myocardial blood flow in patients with heart failure secondary to ischemic or nonischemic cardiomyopathy

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Cited by (26)

  • The Potential of Clinical Phenotyping of Heart Failure With Imaging Biomarkers for Guiding Therapies: A Focused Update

    2017, JACC: Cardiovascular Imaging
    Citation Excerpt :

    Several positron emission tomography (PET) studies have demonstrated abnormal coronary flow reserve in dilated and hypertrophic cardiomyopathy patients, with the subset of patients exhibiting blunted flow reserve having a more unfavorable natural history (24,25). Such data support the relevance of the perfusion abnormalities rather than simply classifying them as false-positive if epicardial CAD is not present (26). On the other hand, extensive perfusion abnormalities in the setting of LV dysfunction are essentially always associated with CAD rather than with dilated cardiomyopathy, especially when the perfusion defects are segmental.

  • Cardiac PET/computed tomography applications and cardiovascular outcome

    2015, PET Clinics
    Citation Excerpt :

    PET assessment of MBF at rest and during different forms of vasomotor stress have been used to verify and follow up the effects of alterations in lifestyle, loss of body weight, and/or preventive medical care on coronary circulatory function in individuals with subclinical or with clinically manifest CAD.3,14,64 Flow responses to vasomotor stress or the coronary vasodilator capacity could be improved with antioxidant challenges, regular exercise, preventive medical care, and euglycemic control with antidiabetic medication in individuals with cardiovascular risk.65–69 More specifically, angiotensin II receptor blocker (ARB) with olmesartan was shown to restore endothelium-related MBF responses to CPT stimulation in patients with essential hypertension.70

  • Quantitative assessment of myocardial blood flow - Clinical and research applications

    2014, Seminars in Nuclear Medicine
    Citation Excerpt :

    PET measurements of MBF may be used to monitor the effects of pharmacologic interventions or lifestyle modification on coronary circulatory function in patients with and without manifest CAD.10,81 For example, PET flow studies have been used to denote an improvement in endothelial dysfunction in patients with cardiovascular risk with a regular exercise program, preventive medical care, antioxidant supplementation with vitamin C, and euglycemic control with antidiabetic medication.140-144 In patients with untreated essential hypertension, angiotensin II receptor blocker (ARB) improved endothelium-related MBF increases to sympathetic stimulation with CPT.145

  • Journey in evolution of nuclear cardiology: Will there be another quantum leap with the f-18-labeled myocardial perfusion tracers?

    2012, JACC: Cardiovascular Imaging
    Citation Excerpt :

    The clinical integration of quantitative rest and maximum MBF and absolute and relative MFR, assessed by PET, can now be used to guide invasive procedures and medical lifestyle treatment and their outcomes (25–29). Such quantitative PET flow measurements have been used to demonstrate improvement in endothelial dysfunction and myocardial ischemia in patients with advanced CAD after medical treatment, vitamin C, and a regular exercise program (26–32). Beyond the well-established diagnostic value of myocardial perfusion with PET, emerging data suggest the incremental prognostic value of absolute MBF and MFR in patients with suspected CAD.

  • Molecular imaging in heart failure

    2007, Current Opinion in Biotechnology
    Citation Excerpt :

    It is also likely that the beneficial effects of long-term β-adrenergic receptor and RAS antagonists in HF are, at least in part, due to a switch in cardiomyocyte metabolism from fatty acid to glucose uptake and oxidation [5••]. Favorable redistribution in absolute blood flow and associated increases in regional and global LV function have also been shown with β-adrenergic receptor blockers (Figure 1) [6]. Several nuclear molecular probes have been used to determine myocardial substrate utilization in HF.

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