How many patients with ischemic cardiomyopathy exhibit viable myocardium?
References (19)
- et al.
Regional wall motion index for infarct and non-infarct region after reperfusion in acute myocardial infarctioncomparison with global wall motion index
J Am Soc Echocardiogr
(1989) - et al.
Improvement of left ventricular ejection fraction, heart failure symptoms and prognosis after revascularization in patients with chronic coronary artery disease and viable myocardium detected by dobutamine stress echocardiography
J Am Coll Cardiol
(1999) - et al.
Preoperative positron emission tomographic viability assessment and preioperative and postoperative risk in patients with advanced ischemic heart disease
J Am Coll Cardiol
(1997) - et al.
Clinical outcome of patients with advanced coronary artery disease after viability studies with positron emission tomography
J Am Coll Cardiol
(1992) - et al.
Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction
Am J Cardiol
(1994) - et al.
Agreement and disagreement between “metabolic viability” and “contractile reserve” in akinetic myocardium
J Nucl Cardiol
(1999) - et al.
Chronic heart failure in the United States. A manifestation of coronary artery disease
Circulation
(1998) - et al.
Medical management of heart failure secondary to coronary artery disease
Coron Art Disease
(1998) - et al.
Donor availability as the primary determinant of the future of heart transplantation
JAMA
(1986)
Cited by (21)
Impact of Ischemic Heart Failure Etiology on Cardiac Recovery During Mechanical Unloading
2016, Journal of the American College of CardiologyCitation Excerpt :We believe improvement of myocardial function in ICM may depend on other factors. For example, up to 50% of patients with advanced ICM have hibernating myocardium (38–42), but do not undergo revascularization for several reasons. LVAD support in this population offers a stable platform to test the viable and jeopardized myocardium at risk as a potential therapeutic target to induce reverse remodeling and myocardial recovery.
Contrast-enhanced cardiac magnetic resonance imaging
2012, Magnetic Resonance Imaging Clinics of North AmericaCitation Excerpt :Alternatively, hibernation is a state of reversible suppressed contractility and energy demands in “chronically” ischemic myocardium and may protect against development of irreversible injury.85 Several studies have reported the presence of substantial amount of viable myocardium in more than 50% of patients with chronic ischemic heart disease.86,87 Many retrospective studies have suggested that the presence of viable myocardium is predictive of improved left ventricular contractility and overall outcome on revascularization.86–94
Myocardial Viability Imaging: Does It Still Have a Role in Patient Selection Prior to Coronary Revascularisation?
2012, Heart Lung and CirculationCitation Excerpt :In contrast, hibernating myocardium has been defined as a state of down-regulated contractile function in non-infarcted myocardium in the setting of severe coronary stenosis that improves after revascularisation [1,2,5]. A substantial amount of hibernating myocardium may be found in up to 50% of patients with ischaemic LV systolic dysfunction [6,7]. Importantly, hibernating myocardium requires the restoration of a normal blood supply for an improvement in contractile function; global increases in left ventricular ejection fraction (LVEF) following coronary artery bypass grafting (CABG) may be seen in as many as 40% of patients with ischaemic LV ventricular dysfunction [8].
Evaluation of Myocardial Viability With Cardiac Magnetic Resonance Imaging
2011, Progress in Cardiovascular DiseasesCitation Excerpt :Contractile recovery in this “stunned” state may occur spontaneously many weeks to months after restoration of a normal blood supply to the previously ischemic myocardium.2,6,7 Conversely, a substantial amount of hibernating myocardium may be found in up to 50% of patients with ischemic cardiomyopathy.8,9 Importantly, hibernating myocardium requires the restoration of a normal blood supply for an improvement in contractile function; global increases in left ventricular (LV) ejection fraction after coronary artery bypass grafting may be seen in as many as 40% of patients with ischemic cardiomyopathy.10
Clinical relevance of hibernating myocardium in ischemic left ventricular dysfunction
2010, American Journal of MedicineCitation Excerpt :Multiple factors determine the accuracy to predict outcome after revascularization (Table 2). The amount of dysfunctional but viable myocardium is an important determinant of improvement in left ventricular ejection fraction after revascularization,15 and approximately 50% of the patients with ischemic left ventricular dysfunction have a clinically significant amount of viable myocardium.16-18 However, the precise extent of viable myocardium that is needed to result in improvement of left ventricular ejection is unclear, and cutoff values ranging from 8% to 50% of the left ventricle being viable have been proposed.
Interaction between two predictors of functional outcome after revascularization in ischemic cardiomyopathy: Left ventricular volume and amount of viable myocardium
2008, Journal of Thoracic and Cardiovascular Surgery