How many patients with ischemic cardiomyopathy exhibit viable myocardium?

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Cited by (21)

  • Impact of Ischemic Heart Failure Etiology on Cardiac Recovery During Mechanical Unloading

    2016, Journal of the American College of Cardiology
    Citation Excerpt :

    We believe improvement of myocardial function in ICM may depend on other factors. For example, up to 50% of patients with advanced ICM have hibernating myocardium (38–42), but do not undergo revascularization for several reasons. LVAD support in this population offers a stable platform to test the viable and jeopardized myocardium at risk as a potential therapeutic target to induce reverse remodeling and myocardial recovery.

  • Contrast-enhanced cardiac magnetic resonance imaging

    2012, Magnetic Resonance Imaging Clinics of North America
    Citation Excerpt :

    Alternatively, hibernation is a state of reversible suppressed contractility and energy demands in “chronically” ischemic myocardium and may protect against development of irreversible injury.85 Several studies have reported the presence of substantial amount of viable myocardium in more than 50% of patients with chronic ischemic heart disease.86,87 Many retrospective studies have suggested that the presence of viable myocardium is predictive of improved left ventricular contractility and overall outcome on revascularization.86–94

  • Myocardial Viability Imaging: Does It Still Have a Role in Patient Selection Prior to Coronary Revascularisation?

    2012, Heart Lung and Circulation
    Citation Excerpt :

    In contrast, hibernating myocardium has been defined as a state of down-regulated contractile function in non-infarcted myocardium in the setting of severe coronary stenosis that improves after revascularisation [1,2,5]. A substantial amount of hibernating myocardium may be found in up to 50% of patients with ischaemic LV systolic dysfunction [6,7]. Importantly, hibernating myocardium requires the restoration of a normal blood supply for an improvement in contractile function; global increases in left ventricular ejection fraction (LVEF) following coronary artery bypass grafting (CABG) may be seen in as many as 40% of patients with ischaemic LV ventricular dysfunction [8].

  • Evaluation of Myocardial Viability With Cardiac Magnetic Resonance Imaging

    2011, Progress in Cardiovascular Diseases
    Citation Excerpt :

    Contractile recovery in this “stunned” state may occur spontaneously many weeks to months after restoration of a normal blood supply to the previously ischemic myocardium.2,6,7 Conversely, a substantial amount of hibernating myocardium may be found in up to 50% of patients with ischemic cardiomyopathy.8,9 Importantly, hibernating myocardium requires the restoration of a normal blood supply for an improvement in contractile function; global increases in left ventricular (LV) ejection fraction after coronary artery bypass grafting may be seen in as many as 40% of patients with ischemic cardiomyopathy.10

  • Clinical relevance of hibernating myocardium in ischemic left ventricular dysfunction

    2010, American Journal of Medicine
    Citation Excerpt :

    Multiple factors determine the accuracy to predict outcome after revascularization (Table 2). The amount of dysfunctional but viable myocardium is an important determinant of improvement in left ventricular ejection fraction after revascularization,15 and approximately 50% of the patients with ischemic left ventricular dysfunction have a clinically significant amount of viable myocardium.16-18 However, the precise extent of viable myocardium that is needed to result in improvement of left ventricular ejection is unclear, and cutoff values ranging from 8% to 50% of the left ventricle being viable have been proposed.

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