The clinical use of radionuclide bone marrow imaging
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Cited by (55)
Gamma camera imaging in hematological diseases
2022, Nuclear Medicine and Molecular Imaging: Volume 1-4Focal nodular and diffuse haematopoietic marrow hyperplasia in patients with underlying malignancies: a radiological mimic of malignancy in need of recognition
2017, Clinical RadiologyCitation Excerpt :Unexpectedly, among the present five patients (four FNHMH, one DHMH) who underwent bone scintigraphy, one (patient 3) with FNHMH showed mildly increased bone tracer uptake in the right femur lesser trochanter and T10 vertebral body, indicative of mildly elevated osteoblastic activity in response to the FNHMH, accounting for the mild sclerosis seen at CT. Thus, a positive focus on bone scintigraphy cannot exclude the possibility of FNHMH; and bone marrow scintigraphy may be helpful in differentiating hyperplastic red marrow from neoplastic lesion.21 All biopsy-proven cases of FNHMH in the studies of Marcelo et al.10 and Shigematsu et al.18 showed increased uptake of FDG at PET and may thus be confused with metastatic lesions.10,18
Distribution of proliferating bone marrow in adult cancer patients determined using FLT-PET imaging
2011, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :Most of these data were studied >50 years ago and were determined by weighing bones from cadavers before and after heating and visual inspection of the color of the marrow (7–12). Although data have been published using radionuclides such as 59Fe and 52Fe to estimate the erythroid component and 99mTc-labeled nanocolloids to image the distribution of reticuloendothelial cells, most of these data either provided no quantitative information regarding the distribution of the bone marrow or reflected only a component of hematopoietic marrow function (6, 13, 14). To date, most positron emission tomography (PET) in oncology has used 18F-flurodeoxyglucose (FDG), which is taken up more readily by metabolically active tissues, including most malignancies.
Structural and Functional Imaging of Normal Bone Marrow and Evaluation of Its Age-Related Changes
2007, Seminars in Nuclear MedicineCitation Excerpt :Because of the smaller particle size, sulfur colloid prepared by the hydrogen sulfide bubbling technique (<100 nm) yields better marrow images than that prepared by acid reduction of sodium thiosulfate (100-1,000 nm). Nanocolloids (99mTc-microaggregated human serum albumin and 99mTc-antimony sulfide colloid) demonstrate relative selectivity for bone marrow (15% to 20% of the injected dose) and less hepatic and splenic uptake.30,33,40,41 However, it has been reported that these nanocolloids show greater background and greater urinary bladder activity than 99mTc-SC.
Occupational Intakes of Radionuclides: Part 5
2022, Annals of the ICRP