Invited reviewNew trends in photobiology: The role of the low density lipoprotein receptor pathway in the delivery of lipophilic photosensitizers in the photodynamic therapy of tumours
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2020, European Journal of Pharmaceutical SciencesCitation Excerpt :Therefore, in comparison with AAG, HSA may play a predominant role in carrying and transporting PHOTOCYANINE to the tumor tissues. It was reported that the association of photosensitizers with lipoproteins promotes their selective accumulation into tumor tissues, and then enhances the PDT anticancer activity (Maziere et al., 1991). Therefore, the distribution of PHOTOCYANINE in lipoproteins fractions, such as very low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL), was investigated by the density gradient ultracentrifugation and the concentration of PHOTOCYANINE in the lipoprotein fractions was measured by the fluorescence method.
Upconversion luminescence mediated photodynamic therapy through hydrophilically engineered porphyrin
2019, Chemical Engineering and Processing - Process IntensificationCitation Excerpt :Furthermore, it was found out that the UCNP-PJ probes irradiated under 980 nm laser exhibit comparable efficiency in generation of cytotoxic ROS in comparison with that of the clinically used HMME excited at 635 nm with the same irradiation density. The UCNP-PJ probes are expected to possess tumor targeting ability, as porphyrins can be captured by low density lipoprotein (LDL) receptors on the surfaces of cancer cells and enter the cells through receptor-mediated endocytosis [50]. Therefore, the specific binding assay was performed using LS180 cells which highly express LDL receptors on their surfaces.
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2018, Biomedicine and PharmacotherapyCitation Excerpt :Lipoproteins play an important role in the transport and release of photosensitizer molecules to cancer cells. Several studies show that a photosensitizer bonded non-covalently to LDL prior to administration leads to an increase in PDT efficiency compared to the administration of the photosensitizer itself (Scheme 3) [63,69,70]. Electroporation (EP) is a technique of reversible or irreversible cell membrane unsealing induced by electrical pulses.