Improved synthesis of some commonly used PET radioligands by the use of [11C]methyl triflate

doi:10.1016/0969-8051(94)00083-V

Nuclear Medicine and Biology

Volume 22, Issue 2, February 1995, Pages 235-239

https://doi.org/10.1016/0969-8051(94)00083-V Get rights and content

Abstract

[¹¹C]Methyl triflate was compared with [¹¹C]methyl iodide as a labelled precursor in the synthesis of some commonly used PET radioligands,l-[¹¹C]deprenyl, [¹¹C]m-hydroxyephedrine (MHED), [¹¹C]β-CIT, [¹¹C]β-CFT and [¹¹C]SCH 39166 which have been prepared previously in comparatively low yields from [¹¹C]methyl iodide. A new dopamine reuptake radioligand, [¹¹C]α-CIT, was also prepared. The results demonstrate that higher yields are obtained with shorter reaction times, lower reaction temperatures and smaller amounts of precursors with [¹¹C]methyl triflate.

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Improved synthesis of some commonly used PET radioligands by the use of [11C]methyl triflate

Abstract

Appl. Radiot. Isot.

Appl. Radiat. Isot.

Appl. Radiat. Isot.

Int. J. Appl. Radiat. Isot.

Int. J. Appl. Radiat. Isot.

Nucl. Med. Biol.

Synthesis, ligand binding, QSAR, and CoMFA study of 3-β-(p-substituted phenyl)tropane 2-β-carboxylic acid methyl esters

J. Med. Chem.

Compounds affecting the central nervous system. 3β-Phenyltropane-2-carboxylic esters and analogs

J. Med. Chem.

Improved synthesis of some commonly used PET radioligands by the use of [¹¹C]methyl triflate