Evaluation of a new DTPA-derivative chelator: Comparative biodistribution and imaging studies of 111In-labeled B3 monoclonal antibody in athymic mice bearing human epidermoid carcinoma xenografts
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Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors
2012, Journal of Controlled ReleaseCitation Excerpt :Alexa-647-B3 was purified with a size exclusion PD-10 column (GE Healthcare Bio-Sciences AB, Uppsala, Sweden) eluted with PBS. Radiolabeling with 90Y was performed using a method reported previously [31]. Briefly, 10 mCi of 90YCl3 (PerkinElmer, Boston, MA; 10 mCi/40 μl of 0.05 M HC1) was adjusted to pH 4.2 with a 200 ml of buffer solution containing 0.30 M sodium acetate and 0.040 M sodium ascorbate in a polypropylene vial.
Combined-modality radioimmunotherapy: Synergistic effect of paclitaxel and additive effect of bevacizumab
2012, Nuclear Medicine and BiologyCitation Excerpt :In this study, we used a mouse model of human A431 tumor which overexpresses Ley antigen. B3 conjugated with 2-(p-SCN-Bz)-6-methyl-DTPA (MX) was radiolabeled with 90Y using a method reported previously [53]. Briefly, 10 mCi of 90YCl3 (PerkinElmer, Boston, MA, USA; 10 mCi/40 μl of 0.05 M HC1) was adjusted to pH 4.2 with 200 μl of buffer solution containing 0.30 M sodium acetate and 0.040 M sodium ascorbate in a polypropylene vial.
Effect of chelator conjugation level and injection dose on tumor and organ uptake of <sup>111</sup>In-labeled MORAb-009, an anti-mesothelin antibody
2011, Nuclear Medicine and BiologyCitation Excerpt :The mAb and CHX-A″ concentrations were measured according to the method of Bradford [26] and that of Pippin et al. [27], respectively, to assess the level of CHX-A″ conjugated per MORAb-009. Purified CHX-A″-MORAb-009 (1 mg/ml, 6.7 μM) was labeled with 111InCl3 in 0.2 M sodium acetate (pH 4.5) at 25°C for 1 h. DTPA at a final concentration of 0.2 mM was then added to the reaction solution to bind possible free 111In ion [12]. The labeled product was purified with a size-exclusion PD-10 column (GE Healthcare Bio-Sciences AB, Uppsala, Sweden) eluted with PBS.
Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)-infected nonhuman primates
2009, BloodCitation Excerpt :CDR-OKT4A/hIgG4 mAb was provided by Johnson & Johnson Pharmaceutical Research and Development. The mAb (molecular weight, 150 kDa) was conjugated with the A′′ stereoisomer of 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaacetic acid (CHX-A′′-DTPA, molecular weight, 739; Macrocyclic) as reported previously.6,7 The resulting conjugate CHX-A′′-DTPA-OKT4A/hIgG4 (for simplicity, DTPA-OKT4A/hIgG4; 125 μg) was labeled with 111In (1.4 mCi/4 μL; PerkinElmer Life and Analytical Sciences).
Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclides
2001, Nuclear Medicine and Biology
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Present address: Department of Nuclear Medicine, National Cancer Institute, F. “G. Pascale”, Via M. Semmola, 80131 Naples, Italy.