An efficient radiosynthesis of [18F]fluoromisonidazole
References (24)
- et al.
A large scale manual production of [18F]FDG using a synthetic unit made of sterile disposable components and operated by a master slave manipulator
Appl. Radiat. Isot.
(1990) Misonidazole and other hypoxia markers: metabolism and applications
Int. J. Rad. Oncol. Biol. Phys.
(1986)- et al.
Synthesis and biodistribution of [18F]fluoronitroimidazole: potential in vivo markers of hypoxic tissue
Appl. Radiat. Isot.
(1986) - et al.
Radiolabeled fluoromisonidazole as an imaging agent for tumor hypoxia
Int. J. Radiat. Oncol. Biol. Phys.
(1989) - et al.
Routine production of reactive fluorine-18 fluoride salts from an oxygen-18 water target
Nucl. Med. Biol.
(1988) - et al.
Potential radiosensitizing agents. Dinitroimidazoles
J. Med. Chem.
(1979) - et al.
Aspects of stereochemistry. Part IV. Configuration and some reactions of the 1,3-O-benzylideneglycerols
J. Chem. Soc.
(1960) - et al.
Studies in the nitroimidazole series
Antimicrob Agents Chemother
(1966) - et al.
Cyclic sulfates: useful substrates for selective nucleophilic substitution
J. Org. Chem.
(1990) - et al.
Vicinal diol cyclic sulfates: like epoxides only more reactive
J. Am. Chem. Soc.
(1988)
A radiosynthesis of fluorine-18-fluoromisonidazole
J. Nucl. Med.
(1989)
Synthesis and characterization of congeners of misonidazole for imaging hypoxia
J. Nucl. Med.
(1987)
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Minimization of the amount of Kryptofix 222 - KHCO<inf>3</inf> for applications to microscale <sup>18</sup>F-radiolabeling
2017, Applied Radiation and IsotopesSynthesis of [<sup>18</sup>F]FMISO in a flow-through microfluidic reactor: Development and clinical application
2015, Nuclear Medicine and BiologyCitation Excerpt :Earlier radiosyntheses of [18F]FMISO utilized multi-step procedures that gave low radiochemical yield [5–7]. Lim and Berridge then developed a one-pot, two-step procedure using 1-(2’-nitro-1’-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonylpropanediol (NITTP) as the precursor for [18F]fluorination followed by acidic hydrolysis to remove the protecting group, which resulted in greatly improved radiochemical yield and operational ease (Fig. 1) [8]. This is now the most widely used method for the production of [18F]FMISO.
Synthesis of [<sup>18</sup>F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist’s perspective
2023, EJNMMI Radiopharmacy and Chemistry2-Nitroimidazole Based PET Tracers: Development of a General Synthetic Approach and Fluorination Methodology
2023, European Journal of Organic Chemistry
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