Improved synthesis of 1-[11C]d-glucose
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Cited by (22)
[<sup>11</sup>C]HCN Radiochemistry: Recent Progress and Future Perspectives
2021, European Journal of Organic ChemistryThe chemistry of labeling heterocycles with carbon-11 or fluorine-18 for biomedical imaging
2020, Advances in Heterocyclic ChemistryCitation Excerpt :This has been exploited for the synthesis of [1-11C]d-glucose. Treatment of d-arabinose with [11C]ammonium cyanide at room temperature gave the two aldonitriles [11C]304 and [11C]305, which after reduction with Raney nickel using formic acid as hydrogen donor, gave [1-11C]d-glucose and [1-11C]d-mannose in a ratio of 1.8:1 (Scheme 94) (1993ARI971). These epimers were easily separated with HPLC to give [1-11C]d-glucose in low to moderate formulated yield.
PET radiopharmaceuticals for metabolic imaging in oncology
2004, International Congress SeriesImaging myocardium enzymatic pathways with carbon-11 radiotracers
2004, Methods in EnzymologyCitation Excerpt :The in-house built systems are also the least expensive of the three systems. Ever since the early 1990s, the authors have been involved in the synthesis of 1-[11C]d-glucose.6 The result has been an improved procedure for the production of the desired compound in sufficient quantities for two simultaneous human studies and an additional animal study if needed.7
Quantification of myocardial glucose utilization by PET and 1-carbon-11-glucose
2002, Journal of Nuclear Cardiology