Production of 6-[18F]fluoro-l-DOPA and its metabolism in vivo—a critical review☆
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2015, Bioorganic and Medicinal ChemistryCitation Excerpt :A further limitation is due to the radiolabeling production of [18F]FDOPA. The electrophilic reactions using molecular [18F]F2 or [18F]acetylhypofluorite provide low radiochemical yields of [18F]FDOPA with very low specific radioactivity.6 Although, in addition to the electrophilic reactions, nucleophilic reactions with no-carrier-added [18F]fluoride was also developed for [18F]FDOPA synthesis, there are concerns about the complex multistep reactions with a long production time and enantiomeric purity.7,8
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2014, PET ClinicsCitation Excerpt :18F-DOPA is a large neutral amino acid that resembles natural l-dopa biochemically and presents similar kinetics. It enters the catecholamine metabolic pathway of endogenous l-DOPA both in the brain and peripherally.9,10 The relatively long half-life (110 minutes) of 18F-DOPA makes it suitable for transportation even in centers with no cyclotron facility on site, allows more flexible imaging timings, and offers the possibility for late images, which are very important in some cases.
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