Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89

https://doi.org/10.1016/0883-2889(92)90170-JGet rights and content

Abstract

Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4–7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.

References (18)

There are more references available in the full text version of this article.

Cited by (110)

  • PET Radiochemistry

    2021, Molecular Imaging: Principles and Practice
View all citing articles on Scopus
View full text