The synthesis of no-c arrier-added DL-4-[18F]fluorodeprenyl via the nucleophilic aromatic substitution reaction
References (14)
- et al.
No-carrier-added (NCA) aryl [18F]fluorides via the nucleophilic aromatic substitution of electron rich aromatic rings
J. Fluorine Chem.
(1990) - et al.
A new route for the synthesis of 18F-fluoroaromatic substituted amino acids such as p-fluorophenylalanine
Appl. Radiat. Isot.
(1987) - et al.
Selective, irreversible in vivo binding of [11C]clorgyline and [11C]L-deprenyl in mice: potential for measurement of functional monoamine oxidase activity in brain using positron emission tomography
Biochem. Pharmacol.
(1985) Stereoselectivity and isoenzyme selectivity of monoamine oxidase inhibitors. Enantiomers of amphetamine, N-methylamphetamine and deprenyl
Biochem. Pharmacol.
(1985)- et al.
Turnover of brain monoamine oxidase measured in vivo by positron emission tomography using L-[11C]deprenyl
J. Neurochem.
(1987) - et al.
Displacement of a nitro-group by [18F]fluoride ion. A new route to aryl fluorides of high specific activity
J. Chem. Soc. Chem. Commun.
(1983) - et al.
Labeled aryl fluorides from the nucleophilic displacement of activated nitro groups by 18F-F−
J. Labelled Compd. Radiopharm.
(1983)
Cited by (29)
PET Imaging of Neuroinflammation
2021, Molecular Imaging: Principles and PracticeHPLC analysis of blood-brain barrier penetration of 4-fluorodeprenyl
2015, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :They determined homogeneity of 4-[18F]fluorodeprenyl using both UV and radioactivity detectors. Plenevaux et al. [8,9] found very fast incorporation of 4-[18F]fluorodeprenyl in the brain of mice, and the brain offset of (−)-4-[18F]fluorodeprenyl was faster than that of (−)-deprenyl from the brain. Brain versus blood level shows decreasing ratios such as 2.03, 1.72 and 1.45 following 1, 10 and 60 min following injection (into the lateral tail vein of female albion mice, strain BNL), respectively.
Progesterone receptor targeting with radiolabelled steroids: An approach in predicting breast cancer response to therapy
2013, Journal of Steroid Biochemistry and Molecular BiologySynthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity
2013, Bioorganic and Medicinal ChemistryCitation Excerpt :Imaging brain MAO-B activity by employing [11C]deuterated deprenyl as ligand with PET in humans has been useful for studying neurodegenerative diseases6,7 and epilepsy.8 In recent years several propargylamine derivatives have been labeled with carbon-11 and fluorine-18 to be applied as PET radioligands such as [11C]pargyline,9 [11C]l-deprenyl,10 [11C]deuterium-l-deprenyl,11 [11C]SL25.1188,12 DL-4-[18F]fluorodeprenyl,13 6-[18F]fluoro-N-methyl-N-(prop-2-yn-1-yl)-hexan-1-amine,14 N-[(2S)-1-[18F]fluoro-3-phenylpropan-2-yl]-N-methylprop-2-yn-1-amine,15 [18F]fluororasagiline.16 A multistep radiosynthesis of DL-4-[18F]fluorodeprenyl and undesired radiometabolites such as [18F]fluoroamphetamine and [18F]fluorometamphetamine from N[(2S)-1-[18F]fluoro-3-phenylpropan-2-yl]-N-methyl-prop-2-yn-1-amine and radiometabolite [18F]fluorohexanoic from 6-[18F]fluoro-N-methyl-N-(prop-2-yn-1-yl)hexan-1-amine preclude their efficient routine use.
Synthesis and evaluation of [ <sup>18</sup>F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)
2012, Bioorganic and Medicinal Chemistry