An improved generator for the production of ²¹²Pb and ²¹²Bi from ²²⁴Ra

Abstract

We have developed an improved generator for the production of the alpha emitting radionuclide ²¹²Bi and its parent, ²¹²Pb. These radionuclides are well suited to use as radiotherapeutic agents due to their relatively short half lives and appropriate particle particle emissions. The parent, ²²⁴Ra, is available from a long-lived parent and can be isolated on a generator which produces the daughters in good yield and low breakthrough. The ²¹²Bi can be eluted by itself or in equilibrium with its parent.