Original contributionIn vivo pO2 imaging in the porcine model with perfluorocarbon F-19 NMR at low field
References (37)
- et al.
Oxygensensitive F-19 NMR imaging of the vascular system in vivo
Magn. Reson. Imaging
(1987) - et al.
Effect of oxygen and the lipid spin label TEMPO-laurate on fluorine-19 and proton relaxation rates of the perfluorochemical blood substitute, FC-43 emulsion
J. Magn. Reson.
(1984) - et al.
Practical aspects involved in the design and set up of a 0.15T, 6-coil resistive magnet, whole body NMR imaging facility
Magn. Reson. Imaging
(1984) - Alpha Therapeutic Corporation, 5555 Valley Blvd., Los Angeles, CA 92121 (Distributor) and Green Cross Corporation,...
- Alliance Pharmaceutical Corp., 3040 Science Park Road, San Diego, CA 92121. (Product:...
- HemaGen/PFC. 11810 Borman Drive, St. Louis, MO...
Perfluorochemical emulsions as blood substitutes
The design and development of improved fluorocarbon-based products for use in medicine and biology
Art. Cells Blood Subs Immob. Biotechnol.
(1994)Overview of progress in the fluorocarbon approach to in vivo oxygen delivery. Biomat
Art. Cells Immob. Biotechnol.
(1992)- et al.
The solubility of oxygen in highly fluoridated liquids
J. Fluor. Chem.
(1977)
The biomedical applications of fluorine-19 NMR
Perfluorinated organic liquids and emulsions as biocompatible NMR imaging agents of 19F and dissolved oxygen
MR imaging of the lung using liquid perfluorocarbons
J. Comput. Assist. Tomogr.
A noninvasive assessment of myocardial oxygen tension: 19F NMR spectroscopy of sequestered perfluorocarbon emulsion
Magn. Reson. Med.
Quantitative determination of the partial oxygen pressure in the vitrectomized rabbit eye in vivo using 19F NMR
Magn. Reson. Med.
Measurement of preretinal oxygen tension in vitrectomized human eye using fluorine-19 magnetic resonance spectroscopy
Arch. Ophthalmol.
In vivo oxygen tension and temperature: Simultaneous determination using 19F NMR spectroscopy of perfluorocarbon
Magn. Reson. Med.
Imaging oxygen tension in liver and spleen by 19F NMR
Magn. Reson. Med.
Cited by (35)
Implant-forming polymeric <sup>19</sup>F MRI-tracer with tunable dissolution
2020, Journal of Controlled ReleaseCitation Excerpt :Many tracers have been developed and tested, yet most small-molecule-based tracers frequently suffer from poor or very poor biodistribution due to their hydrophobicity and lipophobicity [1]. Over the last few decades, 19F MRI has become an important tool in many medical applications: [2] it can be used for cellular tracking [3–8], tumor diagnosis [9–12], metabolic studies [13], partial oxygen pressure determination [14,15], inflammation monitoring [16–18], and intra−/extracellular pH measurement [19]. In this study, we investigate stimuli-responsive polymers with a lower critical solution temperature (LCST) [20,21].
New frontiers and developing applications in <sup>19</sup>F NMR
2013, Progress in Nuclear Magnetic Resonance SpectroscopyHypoxia imaging with the nitroimidazole <sup>18</sup>F-FAZA PET tracer: A comparison with OxyLite, EPR oximetry and <sup>19</sup>F-MRI relaxometry
2012, Radiotherapy and OncologyCitation Excerpt :The spin–lattice relaxation rate R1 of 19F nuclei is related to oxygen tension according to a linear function; the higher the slope is and/or the smaller the intercept value is, the greater sensitivity we can achieve. Therefore, the ratio η = slope/intercept has been proposed as a sensitivity index [57]. This ratio derived from the 19F-relaxometry calibration curve of our group was 0.0036 [33].
Non Invasive Physiology and Pharmacology Using 19F Magnetic Resonance
2008, Fluorine and Health: Molecular Imaging, Biomedical Materials and PharmaceuticalsNon-Invasive Physiology and Pharmacology Using <sup>19</sup>F Magnetic Resonance
2008, Fluorine and HealthMeasuring changes in tumor oxygenation
2004, Methods in EnzymologyCitation Excerpt :At any given magnetic field (Bo) and temperature (T), sensitivity to changes in pO2 is given by R1 = a + bpO2. Thus a greater slope is important, and the ratio η = b/a has been proposed as a sensitivity index.128 Generally, a small “a” value (intercept) represents greater sensitivity, but it also generates longer T1 values under hypoxic conditions, potentially increasing data acquisition times.
- ‡
Current affiliation: National Institutes of Health, In Vivo NMR Research Center.
- §
Current affiliation: Philips Laboratories.