International Journal of Radiation Oncology*Biology*Physics
Oncology intelligenceRadiation induction of immediate early genes: Effectors of the radiation-stress response☆
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2017, Revue du Rhumatisme MonographiesPossible involvement of hippocampal immediate-early genes in contextual fear memory deficit induced by cranial irradiation
2016, Neurobiology of Learning and MemoryCitation Excerpt :Although the significance of each IEG expression level was in accordance with each dependent variable (i.e., hippocampal region and time post-CFC training), in the present study, the basal expression levels of IEGs (particularly, c-fos protein) tended to increase in 10 Gy-irradiated hippocampi. A previous study reported upregulation of IEGs or mitogen-activated protein kinases during the acute phase after irradiation (Brisman et al., 2005; Weichselbaum, Hallahan, Fuks, & Kufe, 1994). Thus, the increase in IEGs after irradiation may be related to the radiation-induced stress response and/or derangement of synaptic plasticity in the hippocampus.
Bystander effects as manifestation of intercellular communication of DNA damage and of the cellular oxidative status
2015, Cancer LettersCitation Excerpt :All these downstream responses are of central importance in the induction of inflammation by the innate immune response, but as we will see below they are also part of the general radiation response. High doses of radiation (2–50 Gy) result in the activation of NF-kB [131,132], partly through the mediated activation of ATM [133] (see also above) (Fig. 5). However, NF-κB can also be indirectly activated through IR-generated ROS [134].
Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation
2012, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :It has been well recognized that NF-κB is a crucial transcription factor that plays an important role in regulation of the inflammatory and stress responses [6,7]. Of note, NF-κB activation is also an important contributor to either apoptosis [45] or to cell survival and protection from apoptosis following exposure to DNA-damaging agents in vitro [46,47] and in vivo [10], depending on certain circumstances and cell type. It also is known that NF-κB mediated cytokine production is a complex system leading to positive feedback loops [48,49].
Co-overexpression of TRAIL and Smac sensitizes MDA-MB-231 cells to radiation through apoptosis depending on mitochondrial pathway
2022, Radiation and Environmental Biophysics
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Presented at the 1993 ASTR.O Meeting, New Orleans, LA.