Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on the regional distribution of brain monoamines in the rhesus monkey
References (98)
- et al.
Brain dopamme and the syndromes of Parkinson and Huntington
J. Neurol. Sci.
(1973) - et al.
Regional distribution of catecholamines in monkey cerebral cortex, evidence for a dopaminergic innervation of the primate prefrontal cortex
Neurosci. Lett.
(1978) - et al.
MPP+ can disrupt the nigrostriatal dopamine system by acting in the terminal area
Neuropharmacology
(1986) - et al.
Behavioral and biochemical studies in monkeys made hemiparkinsonian by MPTP
Brain Res.
(1987) - et al.
Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates
Brain Res.
(1979) - et al.
On the aetiology of Parkinson's disease
Lancet
(1983) - et al.
Neurochemical and behavioral effects of systemic and intranigral administration of N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine in the rat
Eur. J. Pharmac.
(1984) - et al.
Chronic Parkinsonism secondary to intravenous injection of meperidine analogues
Psychiat. Res.
(1979) - et al.
Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin l-methyl-4-phenyl-l,2,3,6-tetra-hydropyridine
Neurosci. Lett.
(1986) - et al.
Distribution of free and conjugated dopamine in monkey brain, peripheral tissues and cerebrospinal fluid determined by high-performance liquid chromatography
Brain Res.
(1983)
Differential responsiveness to l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum
Life Sci.
Effects of l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF
Brain Res.
MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate
Neurosci. Lett.
Acute administration of l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) reduces dopamine and serotonin but accelerates norepinephrine metabolism in the rat brain. Effect of chronic pretreatment with MPTP
Eur. J. Pharmac.
l-Methyl-4-phenyl-l,2,3,6-tetrahydro-pyridine-induced parkinsonian syndrome in Macaca fascicularis: which midbrain dopaminergic neurons are lost?
Neurocience
The dopamine neurotoxin l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces histological lesions in the hypothalamus of the common marmoset
Neurosci. Lett.
Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys
Neuroscience
MPTP alters central catecholamine neurons in addition to the nigrostriatal system
Brain Res. Bull.
Neurotoxicity of the meperidine analogue jV-methyl-4-phenyl-l,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse
Eur. J. Pharmac.
Selective retention of MPP+ within the monoaminergic systems of the primate brain following MPTP administration: an in vivo autoradiographic study
Neuroscience
The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment
Eur. J. Pharmac.
Hemiparkinsonism in monkeys after unilateral caudate nucleus infusion of l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP): behavior and histology
Brain Res.
The evolution of nigrostriatal neurochemical changes in the MPTP-treated squirrel monkey
Brain Res.
Differences in the metabolism of MPTP in the rodent and primate: parallel differences in sensitivity to its neurotoxic effects
Life Sci.
Evidence for the release of l-methyl-4-phenyipyridinium (MPP+) from rat striatal neurons in vitro
Eur. J. Pharmac.
Participation of brain monoamine oxidase B form in the neurotoxicity of l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine: relationship between the enzyme inhibition and the neurotoxicity
Neurosci. Lett.
The neurotoxicity of l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its relevance to Parkinson's disease
Neurochem. Int.
Injury of nigral neurons exposed to l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine: a tyrosine hydroxylase immunocytochemical study in monkey
Neuroscience
Neurochemical investigations in vitro with 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP) in preparations of rat brain
Eur. J. Pharmac.
In vivo effect of MPTP on monoamine oxidase activity in mouse striatum
Brain Res.
Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the Macaque monkey include the ventral tegmental area and the locus coeruleus
Neurosci. Lett.
Extrastriatal dopamine in symptomatic and asymptomatic rhesus monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Neurochem. Int.
The neurotoxin MPTP does not reproduce in the rhesus monkey the interregional pattern of striatal dopamine loss typical of human idiopathic Parkinson's disease
Neurosci. Lett.
Long-term effects of repeated methylamphetamine administration on monoamine neurons in the rhesus monkey brain
Brain Res.
Transient depletion of nucleus accumbens dopamine content may contribute to initial akinesia induced by MPTP in common marmosets
Biochem. Pharmac.
Oxidation of the neurotoxic aminé1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP
Biochem. biophys. Res. Commun.
Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP)
Toxic. Lett.
Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease
Brain Res.
Chronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeys
Brain Res.
Production of a Parkinson-like syndrome in the cat with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP): behavior, histology, and biochemistry
Expl Neurol.
Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP
Brain Res.
MPTP-induced Parkinsonism in monkeys: mechanism of action, selectivity and pathophysiology
Gen. Pharmac.
Deficits in behavioral initiation and execution processes in monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism
Neurosci. Lett.
Serotonergic conversion of MPTP and dopaminergic accumulation of MPP+
Fedn Eur. biochem. Socs Lett.
Further treatment with MPTP does not produce Parkinsonism in marmosets showing behavioural recovery from motor deficits induced by an earlier exposure to the toxin
Neuropharmacology
An immunohistochemical study of the acute and long-term effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the marmoset
Neuroscience
Age-related changes in multiple neurotransmitter systems in the monkey brain
Neurobiol. Aging
Animal models of Parkinsonism using selective neurotoxins: clinical and basic implications
Int. Rev. Neurobiol.
Permanent human Parkinsonism due to l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases
Neurology
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2021, Progress in Brain ResearchCitation Excerpt :The inclusion of an experimental group only injured with MDMA is required to definitely answer the question of the potential toxicity of MDMA toward the DA system. On another side, as previously shown (Masilamoni and Smith, 2018; Pifl et al., 1991), MPTP, depending on its concentration and administration regimen, can have consequences on other monoaminergic systems. In our hands, MPTP administrated acutely at high doses injures the 5-HT system at both terminals and cell bodies levels.
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2020, NeuropharmacologyCitation Excerpt :The results of the present work are congruent with previous biochemical findings obtained using the same experimental protocol. HPLC analyses of striatal 5-HT and 5-HIAA showed no concentration changes in MPTP-intoxicated monkeys compared to controls (Blesa et al., 2012), coinciding with the striatal serotonin HPLC results published in other MPTP monkey models (rostral caudate and putamen in Pifl et al., 1991; caudate in Franke et al., 2016). It is relevant to point out that the PD model used here has several strengths.