Elsevier

Neuroscience Letters

Volume 101, Issue 3, 3 July 1989, Pages 247-252
Neuroscience Letters

Quantitative autoradiography of nicotinic receptors in large cryosections of human brain hemispheres

https://doi.org/10.1016/0304-3940(89)90540-5Get rights and content

Abstract

In vitro quantitative autoradiography was used to visualize nicotinic receptors in large cryosections of human brain hemispheres. Sections 80 μm thick of human brain hemispheres were incubated with (−)-[3H]nicotine and the distribution of nicotinic receptors in human brain was studied. Increasing numbers of nicotinic binding sites were observed in the: hippocampus < cortex < cerebellum < substantia nigra < putamen < periaqueductal gray. The cartography of nicotinic receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.

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