Elsevier

Neuroscience Letters

Volume 72, Issue 1, 3 December 1986, Pages 115-120
Neuroscience Letters

Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains

https://doi.org/10.1016/0304-3940(86)90629-4Get rights and content

Abstract

Nicotinic cholinergic receptors were measured in human frontal cortex using [3H]nicotine and [3H]acetylcholine (in the presence of atropine) as receptor ligands. A parallel marked reduction in number of [3H]nicotine (52%; P<0.01) and [3H]acetylcholine (−55%; P<0.05) binding was found in the frontal cortex of Alzheimer brains (AD/SDAT) when compared to age-matched control brains. As a comparison the number of muscarinic receptors was quantified using [3H]quinuclidinyl benzilate and found to be significantly increased (+23%; P<0.01) in AD/SDAT compared to controls.

References (26)

  • P.B.S. Clarke et al.

    Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine and 125I-alpha-bungarotoxin

    J. Neurosci.

    (1985)
  • M.F. Giorguieff-Chesselet et al.

    Regulation of dopamine release by presynaptic nicotinic receptors in rat striatal slices: effect of nicotine in low concentration

    Life Sci.

    (1979)
  • E.G. Gray et al.

    The isolation of nerve endings from brain in an electron microscopic study of cell fragments derived by homogenization and centrifugation

    J. Anat.

    (1962)
  • Cited by (296)

    • Attentional impairments to novel images in dementia

      2020, Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2
    View all citing articles on Scopus
    View full text