Acetylcholinesterase-rich pyramidal neurons in alzheimer's disease
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AChE as a spark in the Alzheimer's blaze – Antagonizing effect of a cyclized variant
2023, Ageing Research ReviewsCitation Excerpt :Both the cholinergic as well as non-cholinergic neuronal regions comprise of AChE, however the functional importance of AChE in non-cholinergic system is yet to be understood. It has been revealed that, even in cholinergic brain areas, curbed AChE potential in AD brain is not the consequence of deficit of cholinergic neurons alone, as reduction in the cholinergic (AChE-rich) fibers in the neuronal cortex of AD patients is not associated with the number of neurons abundant in AChE (Heckers et al., 1992). Thus, notably changes in AChE concentration may not correlate with altered cholinergic neurotransmission (García-Ayllón et al., 2011).
The cholinergic system and Parkinson disease
2011, Behavioural Brain ResearchCholinesterase inhibitors affect brain potentials in amnestic mild cognitive impairment
2007, Brain ResearchCitation Excerpt :These findings suggest that MCI can be a precursor of Alzheimer's disease. Cholinergic processes in neocortical areas are affected in Alzheimer's disease (Geula and Mesulam, 1989; Heckers et al., 1992) and are particularly apparent late in the course of Alzheimer's disease when cognitive and behavioral functions are severely impaired (Davis et al., 1999). Cholinesterase inhibitors (ChEIs) that serve to increase the availability of acetylcholine have been used successfully to treat patients with MCI (Petersen et al., 2005) and early stages of Alzheimer's disease (Doody et al., 2001; Rogers et al., 1998; Winblad et al., 2001).
Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter
1998, Journal of Physiology ParisNon-classical actions of cholinesterases: Role in cellular differentiation, tumorigenesis and Alzheimer's disease
1996, Neurochemistry International