ArticleIn vitro degradation of neurotensin in human plasma
References (24)
- et al.
The stability and metabolism of intravenously administered neurotensin in the rat
Peptides
(1982) - et al.
The amino acid sequence of a hypothalamic peptide, neurotensin
J Biol Chem
(1975) - et al.
Characterisation of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine and stomach
J Biol Chem
(1976) - et al.
Elevation of plasma neurotensin during lipid perfusion of rat intestine
Peptides
(1981) - et al.
Release and degradation of neurotensin during perfusion of rat small intestine with lipid
Regul Pept
(1985) - et al.
Isolation of human intestinal neurotensin
J Biol Chem
(1980) - et al.
A study of the concentrations of substance P and neurotensin in the gastrointestinal tract of various mammals
Neuroscience
(1982) - et al.
Characterisation of neurotensin-like immunoreactivity in plasma and tissue extracts from hepatoma patients
Clin Chim Acta
(1985) - et al.
Pharmacological studies of neurotensin, several fragments and analogues in the isolated perfused rat heart
Eur J Pharmacol
(1980) - et al.
Hyrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase
Peptides
(1984)
Characterisation of human plasma neurotensin-like immunoreactivity after fat ingestion
Regul Pept
Structural requirement for the biological activity of neurotensin
Cited by (17)
Positive reinforcing effect of neurotensin microinjection into the ventral pallidum in conditioned place preference test
2015, Behavioural Brain ResearchCitation Excerpt :The diffusion of NT to the surrounding structures is not probable, because NT is degraded by peptidases. The half life time of NT at 37 °C was measured 1.4 min in human plasma [51]. Electrophysiological studies proved that NT can modify the firing rate of dopaminergic neurons in the VTA and in the substantia nigra for more than 7 min [52].
Contribution of neurotensin in the immune and neuroendocrine modulation of normal and abnormal enteric function
2011, Regulatory PeptidesCitation Excerpt :On the other hand, the comparatively increased numbers of activated mast cells that were recently detected in the white adipose tissues from obese humans and mice [93] may lead to a rapid NT degradation (as explained later), and therefore, despite the high NT levels along the GIT, to the significant decrease in systemic and hypothalamic NT content mentioned above. There is evidence that hypothalamic NT content may be modified by circulating NT levels, although this modification must be generally weak, due to NT's rapid degradation, which takes place even under normal conditions [94–96]. First of all, it is well established that particular areas of the hypothalamic–pituitary axis, such as the median eminence, the pituitary portal circulation and the pituitary gland, stand outside the blood–brain barrier [97], allowing NT to directly reach specific hypothalamic nuclei through systemic circulation.
Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1
2011, NeuropeptidesCitation Excerpt :NT is a 13-amino-acid peptide originally isolated in 1973 from bovine hypothalamus (Carraway and Leeman, 1973). NT could be degraded identically to neurotensin 1–8 and neurotensin 1–11 by human plasma in vitro (Lee et al., 1986). Both central and peripheral actions of NT depend on the recognition of the peptide by specific receptors at the plasma membrane of target cells.
The role of neurotensin in positive reinforcement in the rat central nucleus of amygdala
2010, Behavioural Brain ResearchSample handling techniques when analyzing regulatory peptides
1987, Life SciencesCatabolism of neurotensin in the epithelial layer of porcine small intestine
1987, BBA - General Subjects