Research paperSigma-1 receptors modulate functional activity of rat splenocytes
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Cited by (33)
Immunotoxicology of Drugs of Abuse
2018, Comprehensive Toxicology: Third EditionSigma (σ) receptors as potential therapeutic targets to mitigate psychostimulant effects
2014, Advances in PharmacologyCitation Excerpt :Given the historical importance of the dopamine system in mediating psychostimulant effects, it is important to note that σ receptors are found on dopaminergic neurons (Graybiel, Besson, & Weber, 1989; Gundlach et al., 1986). Also, in light of the interplay between the nervous and immune systems, it is noteworthy that σ receptors are expressed in the spleen and other immune cells, including peripheral blood leukocytes and lymphocytes (Carr, De Costa, Radesca, & Blalock, 1991; Liu, Whitlock, Pultz, & Wolfe, 1995; Paul et al., 1994; Wolfe et al., 1988). They are also found on endothelial cells, which could have implications for blood–brain barrier (BBB) functions and/or vascular events related to cocaine exposure (Wilbert-Lampen, Seliger, Zilker, & Arendt, 1998).
Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands
2012, Brain ResearchCitation Excerpt :In addition to these effects of Sigma1R on ion channels physiology, Sigma1R ligands have been reported to show immuno-modulatory effects. Suppression of splenocyte proliferation and NK cell activity (Liu et al., 1995; Carr et al., 1992), inhibition of mitogen induced lymphocyte proliferative response (Casellas et al., 1994), IL-10 mediated suppression of antitumor immunity (Zhu et al., 2003), and enhancement of monocyte transmigration (Yao et al., 2010) have been ascribed to various Sigma 1R ligands including haloperidol and ketamine (Leykin et al., 1997; Rofael et al., 2003; Ohta et al., 2009). The precise mechanisms of these immuno-modulatory effects remain largely unresolved.
Cocaine modulates cytokine and enhances tumor growth through sigma receptors
2004, Journal of NeuroimmunologyMultiple pathways of σ<inf>1</inf> receptor ligand uptakes into primary cultured neuronal cells
2001, European Journal of Pharmacology